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Lipid-A-disaharid sintaza
Identifikatori
EC broj	2.4.1.182
CAS broj	105843-81-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Lipid-A-disaharid sintaza (EC 2.4.1.182, Lipid-A-disaccharide synthase) je enzim sa sistematskim imenom UDP-2,3-bis(3-hidroksitetradekanoil)glukozamin:2,3-bis-(3-hidroksitetradekanoil)-beta-D-glukozaminil-1-fosfat 2,3-bis(3-hidroksitetradekanoil)-glukozaminiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-2,3-bis(3-hidroksitetradekanoil)glukozamin + 2,3-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil 1-fosfat

\rightleftharpoons

UDP + 2,3-bis(3-hidroksitetradekanoil)-D-glukozaminil-(1->6)-beta-D-2,3-bis(3-hidroksitetradekanoil)-beta-D-glukozaminil 1-fosfat

Ovaj enzim zajedno sa EC 2.3.1.129 (acil-[acil-nosilac-protein]---UDP-N-acetilglukozamin O-aciltransferaza) i EC 2.7.1.130 (tetraacildisaharid 4'-kinaza) učestvuje u biosintezi fosforilisanog glikolipida, Lipid A, u spoljašnjoj membrani Escherichia coli.

Reference

↑ Crowell, D.N., Reznikoff, W.S. and Raetz, C.R.H. (1987). „Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase”. J. Bacteriol. 169: 5727-5734. PMID 2824445.
↑ Ray, B.L., Painter, G. and Raetz, C.R.H. (1984). „The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli”. J. Biol. Chem. 259: 4852-4859. PMID 6370995.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Lipid-A-disaccharide+synthase

[1] Crowell, D.N., Reznikoff, W.S. and Raetz, C.R.H. (1987). „Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase”. J. Bacteriol. 169: 5727-5734. PMID 2824445.

[2] Ray, B.L., Painter, G. and Raetz, C.R.H. (1984). „The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli”. J. Biol. Chem. 259: 4852-4859. PMID 6370995.

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