Laktozilkeramid 1,3-N-acetil-b-D-glukozaminiltransferaza

Laktozilkeramid 1,3-N-acetil-b-D-glukozaminiltransferaza
Identifikatori
EC broj 2.4.1.206
CAS broj 83682-80-8
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Laktozilkeramid 1,3-N-acetil-b-D-glukozaminiltransferaza (EC 2.4.1.206, LA2 sintaza, beta1->3-N-acetilglukozaminiltransferaza, uridin difosfoacetilglukozamin-laktozilkeramid beta-acetilglukozaminiltransferaza, laktozilkeramid beta-acetilglukozaminiltransferaza, UDP-N-acetil-D-glukozamin:D-galaktozil-1,4-beta-D-glukozilkeramid beta-1,3-acetilglukozaminiltransferaza, UDP-N-acetil-D-glukozamin:beta-D-galaktozil-(1->4)-beta-D-glukozil(1<->1)keramid 3-beta-N-acetilglukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid 3-beta-N-acetilglukozaminiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid UDP + N-acetil-beta-D-glukozaminil-(1->3)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid

Reference

  1. ↑ Gottfries, J., Percy, A.K., Maansson, J.-E., Fredman, P., Wilkstrand, C.J., Friedman, H.S., Bigner, D.D. and Svennerholm, L. (1991). „Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas”. Biochim. Biophys. Acta 1081: 253-261. PMID 1825612. 
  2. ↑ Holmes, E.H., Hakomori, S. and Ostrander, G.K. (1987). „Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed β1→3N-acetylglucosaminyltransferase”. J. Biol. Chem. 262: 15649-15658. PMID 2960671. 
  3. ↑ Percy, A.K., Gottfries, J., Vilbergsson, G., Maansson, J.E. and Svennerholm, J. (1991). „Glycosphingolipid glycosyltransferases in human fetal brain”. J. Neurochem. 56: 1461-1465. PMID 1901591. 

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