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L-triptofan—piruvat aminotransferaza
Identifikatori
EC broj	2.6.1.99
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

L-triptofan—piruvat aminotransferaza (EC 2.6.1.99, TAA1 (gen), vt2 (gen)) je enzim sa sistematskim imenom L-triptofan:piruvat aminotransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-triptofan + piruvat

\rightleftharpoons

indol-3-piruvat + L-alanin

Ovaj biljni enzim, zajedno sa EC 1.14.13.168, indol-3-piruvat monooksigenazom, je je odgovoran za biosintezu biljnog hormona indol-3-acetata iz L-triptofana.

Reference

↑ Tao, Y., Ferrer, J.L., Ljung, K., Pojer, F., Hong, F., Long, J.A., Li, L., Moreno, J.E., Bowman, M.E., Ivans, L.J., Cheng, Y., Lim, J., Zhao, Y., Ballare, C.L., Sandberg, G., Noel, J.P. and Chory, J. (2008). „Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants”. Cell 133: 164-176. PMID 18394996.
↑ Mashiguchi, K., Tanaka, K., Sakai, T., Sugawara, S., Kawaide, H., Natsume, M., Hanada, A., Yaeno, T., Shirasu, K., Yao, H., McSteen, P., Zhao, Y., Hayashi, K., Kamiya, Y. and Kasahara, H. (2011). „The main auxin biosynthesis pathway in Arabidopsis”. Proc. Natl. Acad. Sci. USA 108: 18512-18517. PMID 22025724.
↑ Phillips, K.A., Skirpan, A.L., Liu, X., Christensen, A., Slewinski, T.L., Hudson, C., Barazesh, S., Cohen, J.D., Malcomber, S. and McSteen, P. (2011). „vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize”. Plant Cell 23: 550-566. PMID 21335375.
↑ Zhao, Y. (2012). „Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants”. Mol. Plant 5: 334-338. PMID 22155950.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH L-tryptophan---pyruvate+aminotransferase

[1] Tao, Y., Ferrer, J.L., Ljung, K., Pojer, F., Hong, F., Long, J.A., Li, L., Moreno, J.E., Bowman, M.E., Ivans, L.J., Cheng, Y., Lim, J., Zhao, Y., Ballare, C.L., Sandberg, G., Noel, J.P. and Chory, J. (2008). „Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants”. Cell 133: 164-176. PMID 18394996.

[2] Mashiguchi, K., Tanaka, K., Sakai, T., Sugawara, S., Kawaide, H., Natsume, M., Hanada, A., Yaeno, T., Shirasu, K., Yao, H., McSteen, P., Zhao, Y., Hayashi, K., Kamiya, Y. and Kasahara, H. (2011). „The main auxin biosynthesis pathway in Arabidopsis”. Proc. Natl. Acad. Sci. USA 108: 18512-18517. PMID 22025724.

[3] Phillips, K.A., Skirpan, A.L., Liu, X., Christensen, A., Slewinski, T.L., Hudson, C., Barazesh, S., Cohen, J.D., Malcomber, S. and McSteen, P. (2011). „vanishing tassel2 encodes a grass-specific tryptophan aminotransferase required for vegetative and reproductive development in maize”. Plant Cell 23: 550-566. PMID 21335375.

[4] Zhao, Y. (2012). „Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants”. Mol. Plant 5: 334-338. PMID 22155950.

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