Kvorum-sensing N-acil-homoserinska laktonaza

Kvorum-sensing N-acil-homoserinska laktonaza
Identifikatori
EC broj 3.1.1.81
CAS broj 389867-43-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Kvorum-sensing N-acil-homoserinska laktonaza (EC 3.1.1.81, acil homoserin degradirajući enzim, acil-homoserin laktonska acilaza, AHL laktonaza, AHL-degradirajući enzim, AHL-inaktivirajući enzim, AHLaza, AhlD, AhlK, AiiA, AiiA laktonaza, AiiA-sličan protein, AiiB, AiiC, AttM, delaktonaza, laktonazi sličan enzim, N-acil homoserin laktonaza, N-acil homoserin laktonska hidrolaza, N-acil-homoserin laktonska laktonaza, N-acil-L-homoserin laktonska hidrolaza, kvorum-sensing laktonaza, kvorum-sensing N-acil homoserin laktonska hidrolaza) je enzim sa sistematskim imenom N-acil-L-homoserin-lakton laktonohidrolaza.[1][2][3][4][5][6][7][8][9][10][11] Ovaj enzim katalizuje sledeću hemijsku reakciju

N-acil-L-homoserin lakton + H2O N-acil-L-homoserin

Acil-homoserinske laktone (AHL) formiraju gram negativne bakterije i obično ih koriste kao signalni molekul za međusobnu komunikaciju u procesu kvorum-sensinga. AHL se vezuje za transkripcione faktore i na taj način utiče na ekspresiju gena. Ovim vidom komunikacije bakterije regulišu brojne biološke funkcije, uključujući i sekreciju faktora virulencije.

Reference

  1. ↑ Thomas, P.W., Stone, E.M., Costello, A.L., Tierney, D.L. and Fast, W. (2005). „The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein”. Biochemistry 44: 7559-7569. PMID 15895999. 
  2. ↑ Dong, Y.H., Gusti, A.R., Zhang, Q., Xu, J.L. and Zhang, L.H. (2002). „Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species”. Appl. Environ. Microbiol. 68: 1754-1759. PMID 11916693. 
  3. ↑ Wang, L.H., Weng, L.X., Dong, Y.H. and Zhang, L.H. (2004). „Specificity and enzyme kinetics of the quorum-quenching N-acyl homoserine lactone lactonase (AHL-lactonase)”. J. Biol. Chem. 279: 13645-13651. PMID 14734559. 
  4. ↑ Dong, Y.H., Xu, J.L., Li, X.Z. and Zhang, L.H. (2000). „AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora”. Proc. Natl. Acad. Sci. USA 97: 3526-3531. PMID 10716724. 
  5. ↑ Dong, Y.H., Wang, L.H., Xu, J.L., Zhang, H.B., Zhang, X.F. and Zhang, L.H. (2001). „Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase”. Nature 411: 813-817. PMID 11459062. 
  6. ↑ Lee, S.J., Park, S.Y., Lee, J.J., Yum, D.Y., Koo, B.T. and Lee, J.K. (2002). „Genes encoding the N-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of Bacillus thuringiensis”. Appl. Environ. Microbiol. 68: 3919-3924. PMID 12147491. 
  7. ↑ Park, S.Y., Lee, S.J., Oh, T.K., Oh, J.W., Koo, B.T., Yum, D.Y. and Lee, J.K. (2003). „AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria”. Microbiology 149: 1541-1550. PMID 12777494. 
  8. ↑ Ulrich, R.L. (2004). „Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis”. Appl. Environ. Microbiol. 70: 6173-6180. PMID 15466564. 
  9. ↑ Kim, M.H., Choi, W.C., Kang, H.O., Lee, J.S., Kang, B.S., Kim, K.J., Derewenda, Z.S., Oh, T.K., Lee, C.H. and Lee, J.K. (2005). „The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase”. Proc. Natl. Acad. Sci. USA 102: 17606-17611. PMID 16314577. 
  10. ↑ Liu, D., Lepore, B.W., Petsko, G.A., Thomas, P.W., Stone, E.M., Fast, W. and Ringe, D. (2005). „Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis”. Proc. Natl. Acad. Sci. USA 102: 11882-11887. PMID 16087890. 
  11. ↑ Yang, F., Wang, L.H., Wang, J., Dong, Y.H., Hu, J.Y. and Zhang, L.H. (2005). „Quorum quenching enzyme activity is widely conserved in the sera of mammalian species”. FEBS Lett. 579: 3713-3717. PMID 15963993. 

Literatura

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