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Krotonoil-(acil-nosilac-protein) hidrataza
Identifikatori
EC broj	4.2.1.58
CAS broj	9030-78-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Krotonoil-(acil-nosilac-protein) hidrataza (EC 4.2.1.58, (3R)-3-hidroksibutanoil-(acil-nosilac-protein) hidrolijaza, beta-hidroksibutiril acil nosilac protein (ACP) dehidraza, beta-hidroksibutiril acil nosilac protein dehidraza, enoil acil nosilac protein hidraza, krotonil acil nosilac protein hidrataza, 3-hidroksibutiril acil nosilac protein dehidrataza, beta-hidroksibutiril acil nosilac, proteinska dehidraza, (3R)-3-hidroksibutanoil-(acil-nosilac-protein) hidrolijaza (formira but-2-enoil-(acil-nosilac protein))) je enzim sa sistematskim imenom (3R)-3-hidroksibutanoil-(acil-nosilac protein) hidrolijaza (formira but-2-enoil-(acil-nosilac protein)).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

(3R)-3-hidroksibutanoil-[acil-nosilac protein]

\rightleftharpoons

but-2-enoil-[acil-nosilac protein] + H₂O

Ovaj enzim je specifičan kratkolančane 3-hidroksiacil-[acil-nosilac protein] derivate (C4 do C8).

Reference

↑ Majerus, P.W., Alberts, A.W. and Vagelos, P.R. (1965). „Acyl carrier protein. 3. An enoyl hydrase specific for acyl carrier protein thioesters”. J. Biol. Chem. 240: 618-621. PMID 14275113.
↑ Mizugaki, M., Weeks, G., Toomey, R.E. and Wakil, S.J. (1968). „Studies on the mechanism of fatty acid synthesis. XX. Preparation and general properties of β-hydroxybutyryl acyl carrier protein dehydrase”. J. Biol. Chem. 243: 3661-3670. PMID 5658542.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Crotonoyl-(acyl-carrier-protein)+hydratase

[1] Majerus, P.W., Alberts, A.W. and Vagelos, P.R. (1965). „Acyl carrier protein. 3. An enoyl hydrase specific for acyl carrier protein thioesters”. J. Biol. Chem. 240: 618-621. PMID 14275113.

[2] Mizugaki, M., Weeks, G., Toomey, R.E. and Wakil, S.J. (1968). „Studies on the mechanism of fatty acid synthesis. XX. Preparation and general properties of β-hydroxybutyryl acyl carrier protein dehydrase”. J. Biol. Chem. 243: 3661-3670. PMID 5658542.

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