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Koproporfirinogen dehidrogenaza
Identifikatori
EC broj	1.3.99.22
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Koproporfirinogen dehidrogenaza (EC 1.3.99.22, od kiseonika nezavisna koproporfirinogen-III oksidaza, HemN, radical SAM enzim, koproporfirinogen III oksidaza) je enzim sa sistematskim imenom koproporfirinogen-III:S-adenozil-L-metionin oksidoreduktaza (dekarboksilacija).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

koproporfirinogen III + 2 S-adenozil-L-metionin

\rightleftharpoons

protoporfirinogen IX + 2 CO₂ + 2 L-metionin + 2 5'-dezoksiadenozin

Ovaj enzim se razlikuje od EC 1.3.3.3, koproporfirinogen oksidaze, po tome što koristi S-adenozil-L-metionin umesto kiseonika kao oksidans. On je prisutan uglavnom kod bakterija, dok eukariote koriste od kiseonika zavisne oksidaze.

Reference

↑ Layer, G., Verfürth, K., Mahlitz, E. and Jahn, D. (2002). „Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli”. J. Biol. Chem. 277: 34136-34142. PMID 12114526.
↑ Layer, G., Moser, J., Heinz, D.W., Jahn, D. and Schubert, W.D. (2003). „Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes”. EMBO J. 22: 6214-6224. PMID 14633981.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Coproporphyrinogen+dehydrogenase

[1] Layer, G., Verfürth, K., Mahlitz, E. and Jahn, D. (2002). „Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli”. J. Biol. Chem. 277: 34136-34142. PMID 12114526.

[2] Layer, G., Moser, J., Heinz, D.W., Jahn, D. and Schubert, W.D. (2003). „Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes”. EMBO J. 22: 6214-6224. PMID 14633981.

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