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Koagulacioni faktor XIIa
Identifikatori
EC broj	3.4.21.38
CAS broj	75216-42-1
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Koagulacioni faktor XIIa (EC 3.4.21.38, Hagemanov faktor (aktiviran), krvno-koagulacioni faktor XIIf, aktivirani beta krvno-koagulacioni faktor XII, prealbuminski aktivator, Hagemanov faktor beta-fragment, Hagemanov faktor fragment HFf, krvno-koagulacioni faktor XIIabeta, prekalikreinski aktivator, kalikreinogenski aktivator) je enzim.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Selectivno razlaganje Arg-Ile veza u faktoru VII čime se formira faktor VIIa, i faktora XI čime se formira faktor XIa

Ovaj enzim takođe aktivira plazminogen i prokalikrein plazme.

Reference

↑ Fujikawa, K. and Davie, E.W. (1981). „Human factor XII (Hageman factor)”. Methods Enzymol. 80: 198-211. PMID 6918768.
↑ Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry 23: 644-650. PMID 6370301.
↑ Que, B.G. and Davie, E.W. (1986). „Characterization of a cDNA coding for human factor XII (Hageman factor)”. Biochemistry 25: 1525-1528. PMID 3011063.
↑ Fujikawa, K. (1988). „Bovine Hageman factor and its fragments”. Methods Enzymol. 163: 54-68. PMID 3237089.
↑ Silverberg, M. and Kaplan, A.P. (1988). „Human Hageman factor and its fragments”. Methods Enzymol. 163: 68-80. PMID 3237092.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Coagulation+factor+XIIa

[1] Fujikawa, K. and Davie, E.W. (1981). „Human factor XII (Hageman factor)”. Methods Enzymol. 80: 198-211. PMID 6918768.

[2] Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry 23: 644-650. PMID 6370301.

[3] Que, B.G. and Davie, E.W. (1986). „Characterization of a cDNA coding for human factor XII (Hageman factor)”. Biochemistry 25: 1525-1528. PMID 3011063.

[4] Fujikawa, K. (1988). „Bovine Hageman factor and its fragments”. Methods Enzymol. 163: 54-68. PMID 3237089.

[5] Silverberg, M. and Kaplan, A.P. (1988). „Human Hageman factor and its fragments”. Methods Enzymol. 163: 68-80. PMID 3237092.

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