Kaspaza-1

Kaspaza-1
Identifikatori
EC broj 3.4.22.36
CAS broj 122191-40-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Kaspaza-1 (EC 3.4.22.36, interleukin 1beta-konvertujući enzim, proteaza VII, proteaza A, interleukin 1beta prekurzorna proteinaza, interleukin 1 konvertujući enzim, interleukin 1beta-konvertujuća endopeptidaza, interleukin-1beta konvertaza, interleukin-1beta konvertujući enzim, interleukin-1beta prekurzorna proteinaza, prointerleukin 1beta proteaza, prekurzor interleukin-1beta konvertujući enzim, pro-interleukinska 1beta proteinaza, ICE) je enzim.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina, pri čemu je neophodno da je Asp ostatak u pozicija P1. Preferentne sekvenca razlaganja je Tyr-Val-Ala-Asp-

Ovaj enzim se javlja u monocitima sisara.

Reference

  1. Howard, A., Kostura, M.J., Thornberry, N., Ding, G.J.., Limjuco, G., Weidner, J., Salley, J.P., Hogquist, K.A., Chaplin, D.D., Mumford, R.A., Schmidt, J.A. and Tocci, M.J. (1991). „IL-1 converting enzyme requires aspartic acid residues for processing of the IL-1β precursor at two distinct sites and does not cleave 31-kDa IL-1α”. J. Immunol. 147: 2964-2969. PMID 1919001. 
  2. Thornberry, N.A., Bull, H.G., Calaycay, J.R., Chapman, K.T., Howard, A.D., Kostura, M.J., Miller, D.K., Molineaux, S.M., Weidner, J.R., Aunins, J., Elliston, K.O., Ayala, J.M., Casano, F (1992). „J., Chin, J., Ding, G.J.-F., Egger, L.A., Gaffney, E.P., Limjuco, G., Palyha, O.C., Raju, S.M., Rolando, A.M., Salley, J.P., Yamin, T.-T. and Tocci, M.J. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes”. Nature 356: 768-774. PMID 1574116. 
  3. Thornberry, N.A. (1994). „Interleukin-1β converting enzyme”. Methods Enzymol. 244: 615-631. PMID 7845238. 
  4. Alnemri, E.S., Livingston, D.J., Nicholson, D.W., Salvesen, G., Thornberry, N.A., Wong, W.W. and Yuan, J.Y. (1996). „Human ICE/CED-3 protease nomenclature”. Cell 87: 171-171. PMID 8861900. 
  5. Margolin, N., Raybuck, S.A., Wilson, K.P., Chen, W.Y., Fox, T., Gu, Y. and Livingston, D.J. (1997). „Substrate and inhibitor specificity of interleukin-1β-converting enzyme and related caspases”. J. Biol. Chem. 272: 7223-7228. PMID 9054418. 
  6. Martinon, F. and Tschopp, J. (2004). „Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases”. Cell 117: 561-574. PMID 15163405. 
  7. Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820. 

Literatura

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