Kalicivirin

Kalicivirin
Identifikatori
EC broj 3.4.22.66
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Kalicivirin (EC 3.4.22.66, Camberwell virus procesujuća peptidaza, Chiba virus procesujuća peptidaza, Norwalk virus procesujuća peptidaza, Southampton virus procesujuća peptidaza, norovirus virus procesujuća peptidaza, calicivirus tripsinu-slična cisteinska proteaza, calicivirus TCP, calicivirus 3C-slična proteaza, calicivirus endopeptidaza, 3C endopeptidaza virusa bolesti zečje bolesti krvarenja) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Endopeptidaza sa a preference for cleavage when the P1 pozicija is occupied by Glu- and the P1' pozicija is occupied by Gly-

Virusi koji su članovi Norovirusnog roda (Caliciviridae familije) su glavni uzrok epidemijskog akutnog viralnog gastroenteritisa.

Reference

  1. ↑ Meyers, G., Rossi, C. and Thiel, H.J. (2004). „Calicivirus endopeptidases”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1380-1382. 
  2. ↑ Wirblich, C., Sibilia, M., Boniotti, M.B., Rossi, C., Thiel, H.J. and Meyers, G. (1995). „3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity”. J. Virol. 69: 7159-7168. PMID 7474137. 
  3. ↑ Martín Alonso, J.M., Casais, R., Boga, J.A. and Parra, F. (1996). „Processing of rabbit hemorrhagic disease virus polyprotein”. J. Virol. 70: 1261-1265. PMID 8551592. 
  4. ↑ Liu, B., Clarke, I.N. and Lambden, P.R. (1996). „Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis”. J. Virol. 70: 2605-2610. PMID 8642693. 
  5. ↑ Liu, B.L., Viljoen, G.J., Clarke, I.N. and Lambden, P.R. (1999). „Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli”. J. Gen. Virol. 80: 291-296. PMID 10073687. 

Literatura

  • Meyers, G., Rossi, C. and Thiel, H.J. (2004). „Calicivirus endopeptidases”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1380-1382. 

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