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Kafeat O-metiltransferaza
Identifikatori
EC broj	2.1.1.68
CAS broj	50936-45-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Kafeat O-metiltransferaza (EC 2.1.1.68, kafeatna metiltransferaza, kafeatna 3-O-metiltransferaza, S-adenozil-L-metionin:kafeinska kiselina-O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:3,4-dihidroksi-trans-cinamat 3-O-metiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + 3,4-dihidroksi-trans-cinamat

\rightleftharpoons

S-adenozil-L-homocistein + 3-metoksi-4-hidroksi-trans-cinamat

3,4-Dihidroksibenzaldehid i katehol mogu da deluju kao akceptori, mada je reakcija sporija.

Reference

↑ Ebel, J., Schaller-Hekeler, B., Knobloch, K.-H., Wellman, E., Grisebach, H. and Hahlbrock, K. (1974). „Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures”. Biochim. Biophys. Acta 362: 417-424. PMID 4472044.
↑ Poulton, J.E. and Butt, V.S. (1975). „Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L)”. Biochim. Biophys. Acta 403: 301-314. PMID 241400.
↑ Shimada, M., Kuroda, H. and Higuchi, T. (1973). „Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase”. Phytochemistry 12: 2873-2875.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Caffeate+O-methyltransferase

[1] Ebel, J., Schaller-Hekeler, B., Knobloch, K.-H., Wellman, E., Grisebach, H. and Hahlbrock, K. (1974). „Coordinated changes in enzyme activities of phenylpropanoid metabolism during the growth of soybean cell suspension cultures”. Biochim. Biophys. Acta 362: 417-424. PMID 4472044.

[2] Poulton, J.E. and Butt, V.S. (1975). „Purification and properties of S-adenosyl-L-methionine: caffeic acid O-methyltransferase from leaves of spinach beet (Beta vulgaris L)”. Biochim. Biophys. Acta 403: 301-314. PMID 241400.

[3] Shimada, M., Kuroda, H. and Higuchi, T. (1973). „Evidence for the formation of methoxyl groups of ferulic and sinapic acid in Bambusa by the same O-methyltransferase”. Phytochemistry 12: 2873-2875.

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