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Izopentenil-difosfatna D-izomeraza
Identifikatori
EC broj	5.3.3.2
CAS broj	9033-27-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Izopentenil-difosfatna D-izomeraza (EC 5.3.3.2, izopentenilpirofosfatna Delta-izomeraza, metilbutenilpirofosfatna izomeraza, izopentenilpirofosfatna izomeraza) je enzim sa sistematskim imenom izopentenil-difosfat Delta3-Delta2-izomeraza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

izopentenil difosfat

\rightleftharpoons

dimetilalil difosfat

Za dejstvo enzima iz Streptomyces sp. vrste CL190 su neophodni FMN i NAD(P)H kofaktori.

Reference

↑ Kaneda, K., Kuzuyama, T., Takagi, M., Hayakawa, Y. and Seto, H. (2001). „An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190”. Proc. Natl. Acad. Sci. USA 98: 932-937. PMID 11158573.
↑ Bishop, J.M. (1983). „Cellular oncogenes and retroviruses”. Annu. Rev. Biochem. 52: 301-354. PMID 6351725.
↑ Agranoff, B.W., Eggerer, H., Henning, U. and Lynen, F. (1960). „Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase”. J. Biol. Chem. 235: 326-332. PMID 13792054.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Isopentenyl-diphosphate+Delta-isomerase

[1] Kaneda, K., Kuzuyama, T., Takagi, M., Hayakawa, Y. and Seto, H. (2001). „An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190”. Proc. Natl. Acad. Sci. USA 98: 932-937. PMID 11158573.

[2] Bishop, J.M. (1983). „Cellular oncogenes and retroviruses”. Annu. Rev. Biochem. 52: 301-354. PMID 6351725.

[3] Agranoff, B.W., Eggerer, H., Henning, U. and Lynen, F. (1960). „Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase”. J. Biol. Chem. 235: 326-332. PMID 13792054.

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