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Ikosanoil-KoA sintaza
Identifikatori
EC broj	2.3.1.119
CAS broj	141256-55-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Ikosanoil-KoA sintaza (EC 2.3.1.119, acil-KoA elongaza, C¹⁸-KoA elongaza, stearoil-KoA elongaza) je enzim sa sistematskim imenom stearoil-KoA:malonil-KoA C-aciltransferaza (dekarboksilacija, oksoacil- i enoil-redukcija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

stearoil-KoA + malonil-KoA + 2 NAD(P)H + 2 H⁺

\rightleftharpoons

ikosanoil-KoA + CO₂ + KoA + 2 NAD(P)⁺ + H₂O

Ikosanoil-KoA može da deluje umesto stearoil-KoA. Ovaj membranski enzim produžava dugolančane masne-acil-KoA.

Reference

↑ Bessoule, J.-J., Lessire, R. and Cassagne, C. (1989). „Partial purification of the acyl-CoA elongase of Allium porrum leaves”. Arch. Biochem. Biophys. 268: 475-484. PMID 2913944.
↑ Bessoule, J.-J., Lessire, R., Rigoulet, M., Guerin, B. and Cassagne, C. (1987). „Fatty acid synthesis in mitochondria from Saccharomyces cerevisiae”. FEBS Lett. 214: 158-162. PMID 3552725.
↑ Lessire, R., Bessoule, J.-J. and Cassagne, C. (1985). „Solubilization of C₁₈ CoA and C₂₀ CoA elongases from Allium porrum L. epidermal-cell microsomes”. FEBS Lett. 187: 314-320.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Icosanoyl-CoA+synthase

[1] Bessoule, J.-J., Lessire, R. and Cassagne, C. (1989). „Partial purification of the acyl-CoA elongase of Allium porrum leaves”. Arch. Biochem. Biophys. 268: 475-484. PMID 2913944.

[2] Bessoule, J.-J., Lessire, R., Rigoulet, M., Guerin, B. and Cassagne, C. (1987). „Fatty acid synthesis in mitochondria from Saccharomyces cerevisiae”. FEBS Lett. 214: 158-162. PMID 3552725.

[3] Lessire, R., Bessoule, J.-J. and Cassagne, C. (1985). „Solubilization of C₁₈ CoA and C₂₀ CoA elongases from Allium porrum L. epidermal-cell microsomes”. FEBS Lett. 187: 314-320.

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