PROFILPELAJAR.COM

Homoizocitrat dehidrogenaza
	Homoizocitrat dehidrogenaza tetramer, Thermus thermophilus
Identifikatori
EC broj	1.1.1.87
CAS broj	9067-90-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Homoizocitrat dehidrogenaza (EC 1.1.1.87, 2-hidroksi-3-karboksiadipat dehidrogenaza, 3-karboksi-2-hidroksiadipat dehidrogenaza, homoizocitratna dehidrogenaza, (-)-1-hidroksi-1,2,4-butantrikarboksilat:NAD⁺ oksidoreduktaza (dekarboksilacija), 3-karboksi-2-hidroksiadipat:NAD⁺ oksidoreduktaza (dekarboksilacija), HICDH) je enzim sa sistematskim imenom (1R,2S)-1-hidroksibutan-1,2,4-trikarboksilat:NAD⁺ oksidoreduktaza (dekarboksilacija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1R,2S)-1-hidroksibutan-1,2,4-trikarboksilat + NAD⁺

\rightleftharpoons

2-oksoadipat + CO₂ + NADH + H⁺

Homoizocitratna dehidrogenaza sačinjava deo puta biosinteze lizina kod gljiva.

Reference

↑ Strassman, M. and Ceci, L.N. (1965). „Enzymatic formation of α-ketoadipic acid from homoisocitric acid”. J. Biol. Chem. 240: 4357-4361. PMID 4284830.
↑ Rowley, B. and Tucci, A.F. (1970). „Homoisocitric dehydrogenase from yeast”. Arch. Biochem. Biophys. 141: 499-510. PMID 4395693.
↑ Zabriskie, T.M. and Jackson, M.D. (2000). „Lysine biosynthesis and metabolism in fungi”. Nat. Prod. Rep. 17: 85-97. PMID 10714900.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Homoisocitrate+dehydrogenase

[1] Strassman, M. and Ceci, L.N. (1965). „Enzymatic formation of α-ketoadipic acid from homoisocitric acid”. J. Biol. Chem. 240: 4357-4361. PMID 4284830.

[2] Rowley, B. and Tucci, A.F. (1970). „Homoisocitric dehydrogenase from yeast”. Arch. Biochem. Biophys. 141: 499-510. PMID 4395693.

[3] Zabriskie, T.M. and Jackson, M.D. (2000). „Lysine biosynthesis and metabolism in fungi”. Nat. Prod. Rep. 17: 85-97. PMID 10714900.

[1]

[2]

[3]