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Holinesteraza
Identifikatori
EC broj	3.1.1.8
CAS broj	2593805
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Holinesteraza (EC 3.1.1.8, pseudoholinesteraza, butirilholin esteraza, nespecifična holinesteraza, holin esteraza II, benzoilholinesteraza, holin esteraza, butirilholinesteraza, propionilholinesteraza, antiholinesteraza, BtChoEase) je enzim sa sistematskim imenom acilholin acilhidrolaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

acilholin + H₂O

\rightleftharpoons

holin + karboksilat

Ovaj enzim deluje mnoštvo holinskih estara.

Reference

↑ Augustinsson, K.-B. (1948). „Cholinesterases. A study in comparative enzymology”. Acta Physiol. Scand. 15, Suppl. 2: -.
↑ Augustinsson, K.-B. and Olsson, B. (1959). „Esterases in the milk and blood plasma of swine. 1. Substrate specificity and electrophoresis studies”. Biochem. J. 71: 477-484. PMID 13638253.
↑ Koelle, G.B. (1953). „Cholinesterases of the tissues and sera of rabbits”. Biochem. J. 53: 217-226. PMID 13032058.
↑ Nachmansohn, D. and Wilson, I.B. (1951). „The enzymic hydrolysis and synthesis of acetylcholine”. Adv. Enzymol. Relat. Subj. Biochem. 12: 259-339. PMID 14885021.
↑ Sawyer, C.H. (1945). „Hydrolysis of choline esters by liver”. Science 101: 385-386.
↑ Strelitz, F. (1944). „Studies on cholinesterase. 4. Purification of pseudo-cholinesterase from horse serum”. Biochem. J. 38: 86-88. PMID 16747753.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Cholinesterase

[1] Augustinsson, K.-B. (1948). „Cholinesterases. A study in comparative enzymology”. Acta Physiol. Scand. 15, Suppl. 2: -.

[2] Augustinsson, K.-B. and Olsson, B. (1959). „Esterases in the milk and blood plasma of swine. 1. Substrate specificity and electrophoresis studies”. Biochem. J. 71: 477-484. PMID 13638253.

[3] Koelle, G.B. (1953). „Cholinesterases of the tissues and sera of rabbits”. Biochem. J. 53: 217-226. PMID 13032058.

[4] Nachmansohn, D. and Wilson, I.B. (1951). „The enzymic hydrolysis and synthesis of acetylcholine”. Adv. Enzymol. Relat. Subj. Biochem. 12: 259-339. PMID 14885021.

[5] Sawyer, C.H. (1945). „Hydrolysis of choline esters by liver”. Science 101: 385-386.

[6] Strelitz, F. (1944). „Studies on cholinesterase. 4. Purification of pseudo-cholinesterase from horse serum”. Biochem. J. 38: 86-88. PMID 16747753.

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