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Holesterol 7a-monooksigenaza
Identifikatori
EC broj	1.14.13.17
CAS broj	9037-53-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Holesterol 7a-monooksigenaza (EC 1.14.13.17, holesterolna 7alfa-hidroksilaza, CYP7A1) je enzim sa sistematskim imenom holesterol,NADPH:kiseonik oksidoreduktaza (7alfa-hidroksilacija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

holesterol + NADPH + H⁺ + O₂

\rightleftharpoons

7alfa-hidroksiholesterol + NADP⁺ + H₂O

Ovaj enzim sadrži hem-tiolat.

Reference

↑ Boyd, G.S., Grimwade, A.M. and Lawson, M.E. (1973). „Studies on rat-liver microsomal cholesterol 7α-hydroxylase”. Eur. J. Biochem. 37: 334-340. PMID 4147676.
↑ Mitton, J.R., Scholan, N.A. and Boyd, G.S. (1971). „The oxidation of cholesterol in rat liver sub-cellular particles. The cholesterol-7α-hydroxylase enzyme system”. Eur. J. Biochem. 20: 569-579. PMID 4397276.
↑ Ogishima, T., Deguchi, S. and Okuda, K. (1987). „Purification and characterization of cholesterol 7α-hydroxylase from rat liver microsomes”. J. Biol. Chem. 262: 7646-7650. PMID 3584134.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Cholesterol+7alpha-monooxygenase

[1] Boyd, G.S., Grimwade, A.M. and Lawson, M.E. (1973). „Studies on rat-liver microsomal cholesterol 7α-hydroxylase”. Eur. J. Biochem. 37: 334-340. PMID 4147676.

[2] Mitton, J.R., Scholan, N.A. and Boyd, G.S. (1971). „The oxidation of cholesterol in rat liver sub-cellular particles. The cholesterol-7α-hydroxylase enzyme system”. Eur. J. Biochem. 20: 569-579. PMID 4397276.

[3] Ogishima, T., Deguchi, S. and Okuda, K. (1987). „Purification and characterization of cholesterol 7α-hydroxylase from rat liver microsomes”. J. Biol. Chem. 262: 7646-7650. PMID 3584134.

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