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Himaza
Identifikatori
EC broj	3.4.21.39
CAS broj	97501-92-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Himaza (EC 3.4.21.39, skeletalna mišićna proteaza, kožna himotriptička proteinaza, mastocitna serinska proteinaza, himaza, skeletalna mišićna (SK) proteaza) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno odvajanje: Phe- > Tyr- > Trp- > Leu-

Ovaj enzim je izolovan iz mastocitnih granulea.

Reference

↑ Woodbury, R.G., Everitt, M. and Neurath, H. (1981). „Mast cell proteases”. Methods Enzymol. 80: 588-609. PMID 7043202.
↑ Powers, J.C., Tanaka, T., Harper, J.W., Minematsu, Y., Barker, L., Lincoln, D., Crumley, K.V., Fraki, J.E., Schechter, N.M., Lazarus, G.G., Nakajima, K., Nakashino, K., Neurath, H. and Woodbury, R.G. (1985). „Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors”. Biochemistry 24: 2048-2058. PMID 3893542.
↑ Johnson, L.A., Moon, K.E. and Eisenberg, M. (1986). „Purification to homogeneity of the human skin chymotryptic proteinase "chymase"”. Anal. Biochem. 155: 358-364. PMID 2425663.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Chymase

[1] Woodbury, R.G., Everitt, M. and Neurath, H. (1981). „Mast cell proteases”. Methods Enzymol. 80: 588-609. PMID 7043202.

[2] Powers, J.C., Tanaka, T., Harper, J.W., Minematsu, Y., Barker, L., Lincoln, D., Crumley, K.V., Fraki, J.E., Schechter, N.M., Lazarus, G.G., Nakajima, K., Nakashino, K., Neurath, H. and Woodbury, R.G. (1985). „Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors”. Biochemistry 24: 2048-2058. PMID 3893542.

[3] Johnson, L.A., Moon, K.E. and Eisenberg, M. (1986). „Purification to homogeneity of the human skin chymotryptic proteinase "chymase"”. Anal. Biochem. 155: 358-364. PMID 2425663.

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