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Hidroperoksidna dehidrataza
Identifikatori
EC broj	4.2.1.92
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Hidroperoksidna dehidrataza (EC 4.2.1.92, hidroperoksidna izomeraza, linoleat hidroperoksidna izomeraza, linoleinsko kiselinska hidroperoksidna izomeraza, HPI, (9Z,11E,14Z)-(13S)-hidroperoksioktadeka-9,11,14-trienoat 12,13-hidrolijaza, (9Z,11E,14Z)-(13S)-hidroperoksioktadeka-9,11,14-trienoat 12,13-hidrolijaza (formira (9Z)-(13S)-12,13-epoksioktadeka-9,11-dienoat), alen oksidna sintaza, AOS) je enzim sa sistematskim imenom (9Z,11E,15Z)-(13S)-hidroperoksioktadeka-9,11,15-trienoat 12,13-hidrolijaza (formira (9Z,15Z)-(13S)-12,13-epoksioktadeka-9,11,15-trienoat).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

(9Z,11E,15Z)-(13S)-hidroperoksioktadeka-9,11,15-trienoat

\rightleftharpoons

(9Z,15Z)-(13S)-12,13-epoksioktadeka-9,11,15-trienoat + H₂O

Ovaj enzim deluje brojne nezasićene masno-kiselinske hidroperokside.

Reference

↑ Esselman, W.J. and Clagett, C.O. (1974). „Products of linoleic hydroperoxide-decomposing enzyme of alfalfa seed”. J. Lipid Res. 15: 173-178. PMID 4208994.
↑ Hamberg, M. (1987). „Mechanism of corn hydroperoxide isomerase - detection of 12,13(S)-oxido-9(Z),11-octadecadienoic acid”. Biochim. Biophys. Acta 920: 76-84.
↑ Hamberg, M. (1988). „Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase”. Biochem. Biophys. Res. Commun. 156: 543-550. PMID 3178850.
↑ Laudert, D., Pfannschmidt, U., Lottspeich, F., Holländer-Czytko, H. and Weiler, E.W. (1996). „Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxide synthase (CYP 74), the first enzyme of the octadecanoid pathway to jasmonates”. Plant Mol. Biol. 31: 323-335. PMID 8756596.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Hydroperoxide+dehydratase

[1] Esselman, W.J. and Clagett, C.O. (1974). „Products of linoleic hydroperoxide-decomposing enzyme of alfalfa seed”. J. Lipid Res. 15: 173-178. PMID 4208994.

[2] Hamberg, M. (1987). „Mechanism of corn hydroperoxide isomerase - detection of 12,13(S)-oxido-9(Z),11-octadecadienoic acid”. Biochim. Biophys. Acta 920: 76-84.

[3] Hamberg, M. (1988). „Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase”. Biochem. Biophys. Res. Commun. 156: 543-550. PMID 3178850.

[4] Laudert, D., Pfannschmidt, U., Lottspeich, F., Holländer-Czytko, H. and Weiler, E.W. (1996). „Cloning, molecular and functional characterization of Arabidopsis thaliana allene oxide synthase (CYP 74), the first enzyme of the octadecanoid pathway to jasmonates”. Plant Mol. Biol. 31: 323-335. PMID 8756596.

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