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Glutation-disulfid reduktaza
	PDB prikaz baziran na 1GRE.
Identifikatori
EC broj	1.8.1.7
CAS broj	9001-48-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Glutation-disulfid reduktaza (EC 1.8.1.7, glutationska reduktaza, glutationska reduktaza (NADPH), NADPH-glutationska reduktaza, GSH reduktaza, GSSG reduktaza, NADPH-GSSG reduktaza, glutationska S-reduktaza, NADPH:oksidovani-glutation oksidoreduktaza) je enzim sa sistematskim imenom glutation:NADP⁺ oksidoreduktaza.^[1]^[2]^[3]^[4]^[5]^[6]^[7] Ovaj enzim katalizuje sledeću hemijsku reakciju

2 glutation + NADP⁺

\rightleftharpoons

glutation disulfid + NADPH + H⁺

Ovaj enzim je dimerni flavoprotein (FAD). Njegova aktivnost je zavisna od redoks-aktivnog disulfida u svakom od aktivnih mesta.

Reference

↑ Pai, E.F., Schirmer, R.H. and Schulz, G.E. (1978). „Structural studies on crystalline glutathione reductase from human erythrocytes”. u: Singer, T.P. and Ondarza, R.N.. Mechanisms of Oxidizing Enzymes. New York: Mechanisms of Oxidizing Enzymes. str. 17-22.
↑ Pigiet, V.P. and Conley, R.R. (1977). „Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography”. J. Biol. Chem. 252: 6367-6372. PMID 330529.
↑ Racker, E. (1955). „Glutathione reductase from bakers' yeast and beef liver”. J. Biol. Chem. 217: 855-865. PMID 13271446.
↑ van Heyningen, R. and Pirie, A. (1953). „Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens”. Biochem. J. 53: 436-444. PMID 13032091.
↑ Worthington, D.J. and Rosemeyer, M.A. (1976). „Glutathione reductase from human erythrocytes. Catalytic properties and aggregation”. Eur. J. Biochem. 67: 231-238. PMID 9277.
↑ Böhmé, C.C., Arscott, L.D., Becker, K., Schirmer, R.H. and Williams, C.H., Jr. (2000). „Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme”. J. Biol. Chem. 275: 37317-37323. PMID 10969088.
↑ Libreros-Minotta, C.A., Pardo, J.P., Mendoza-Hernandez, G. and Rendon, J.L. (1992). „Purification and characterization of glutathione reductase from Rhodospirillum rubrum”. Arch. Biochem. Biophys. 298: 247-253. PMID 1524433.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Glutathione-disulfide+reductase

[1] Pai, E.F., Schirmer, R.H. and Schulz, G.E. (1978). „Structural studies on crystalline glutathione reductase from human erythrocytes”. u: Singer, T.P. and Ondarza, R.N.. Mechanisms of Oxidizing Enzymes. New York: Mechanisms of Oxidizing Enzymes. str. 17-22.

[2] Pigiet, V.P. and Conley, R.R. (1977). „Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography”. J. Biol. Chem. 252: 6367-6372. PMID 330529.

[3] Racker, E. (1955). „Glutathione reductase from bakers' yeast and beef liver”. J. Biol. Chem. 217: 855-865. PMID 13271446.

[4] van Heyningen, R. and Pirie, A. (1953). „Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens”. Biochem. J. 53: 436-444. PMID 13032091.

[5] Worthington, D.J. and Rosemeyer, M.A. (1976). „Glutathione reductase from human erythrocytes. Catalytic properties and aggregation”. Eur. J. Biochem. 67: 231-238. PMID 9277.

[6] Böhmé, C.C., Arscott, L.D., Becker, K., Schirmer, R.H. and Williams, C.H., Jr. (2000). „Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme”. J. Biol. Chem. 275: 37317-37323. PMID 10969088.

[7] Libreros-Minotta, C.A., Pardo, J.P., Mendoza-Hernandez, G. and Rendon, J.L. (1992). „Purification and characterization of glutathione reductase from Rhodospirillum rubrum”. Arch. Biochem. Biophys. 298: 247-253. PMID 1524433.

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