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Glutamat-tRNKGln ligaza
Identifikatori
EC broj	6.1.1.24
CAS broj	9068-76-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Glutamat-tRNKGln ligaza (EC 6.1.1.24, nondiscriminišuća glutamil-tRNK sintetaza) je enzim sa sistematskim imenom L-glutamat:tRNKGlx ligaza (formira AMP).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-glutamat + tRNKGlx

\rightleftharpoons

AMP + difosfat + glutamil-tRNKGlx

Kad ovaj enzim deluje na tRNKGlu, on katalizuje istu reakciju kao EC 6.1.1.17, glutamat-tRNK ligaza.

Reference

↑ Ibba, M. and Söll, D. (2000). „Aminoacyl-tRNA synthesis”. Annu. Rev. Biochem. 69: 617-650. PMID 10966471.
↑ Schmitt, E., Moulinier, L., Fujiwara, S., Imanaka, T., Thierry, J.C. and Moras, D. (1998). „Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation”. EMBO J. 17: 5227-5237. PMID 9724658.
↑ Kim, S.I. and Söll, D. (1998). „Major identity element of glutamine tRNAs from Bacillus subtilis and Escherichia coli in the reaction with B. subtilis glutamyl-tRNA synthetase”. Mol. Cells 8: 459-465. PMID 9749534.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Glutamate---tRNAGln+ligase

[1] Ibba, M. and Söll, D. (2000). „Aminoacyl-tRNA synthesis”. Annu. Rev. Biochem. 69: 617-650. PMID 10966471.

[2] Schmitt, E., Moulinier, L., Fujiwara, S., Imanaka, T., Thierry, J.C. and Moras, D. (1998). „Crystal structure of aspartyl-tRNA synthetase from Pyrococcus kodakaraensis KOD: archaeon specificity and catalytic mechanism of adenylate formation”. EMBO J. 17: 5227-5237. PMID 9724658.

[3] Kim, S.I. and Söll, D. (1998). „Major identity element of glutamine tRNAs from Bacillus subtilis and Escherichia coli in the reaction with B. subtilis glutamyl-tRNA synthetase”. Mol. Cells 8: 459-465. PMID 9749534.

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