Glicilpeptid N-tetradekanoiltransferaza

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Glicilpeptid N-tetradekanoiltransferaza (EC 2.3.1.97, peptid N-miristoiltransferaza, miristoil-KoA-protein N-miristoiltransferaza, miristoil-koenzim A:protein N-miristoil transferaza, miristoilacioni enzim, protein N-miristoiltransferaza) je enzim sa sistematskim imenom tetradekanoil-KoA:glicilpeptid N-tetradekanoiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

tetradekanoil-KoA + glicilpeptid

\rightleftharpoons

KoA + N-tetradekanoilglicilpeptid

Enzim iz kvasca je veoma specifičan za tetradekanoil-KoA, za N-terminalni glicin u oligopeptidima koji sadrže serin u 5-pozicija. Enzim iz srca sisara prenosi grupe na specifične 51 kDa akceptorske proteine.

Reference

↑ Guertin, D., Gris-Miron, L. and Riendeau, D. (1986). „Identification of a 51-kilodalton polypeptide fatty acyl chain acceptor in soluble extracts from mouse cardiac tissue”. Biochem. Cell Biol. 64: 1249-1255. PMID 3566958.
↑ Heuckeroth, R.O., Towler, D.A., Adams, S.P., Glaser, L. and Gordon, J.I. (1988). „11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase”. J. Biol. Chem. 263: 2127-2133. PMID 3123489.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

MeSH Glycylpeptide+N-tetradecanoyltransferase

p r u Proteini: enzimi
Teme	Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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