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Gangliozid galaktoziltransferaza
Identifikatori
EC broj	2.4.1.62
CAS broj	37217-28-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Gangliozid galaktoziltransferaza (EC 2.4.1.62, UDP-galaktoza-keramid galaktoziltransferaza, uridin difosfogalaktoza-keramid galaktoziltransferaza, UDP galaktoza-LAC Tet-keramid alfa-galaktoziltransferaza, UDP-galaktoza-GM2 galaktoziltransferaza, uridin difosfogalaktoza-GM2 galaktoziltransferaza, uridin difosfat D-galaktoza:glikolipid galaktoziltransferaza, UDP-galaktoza:N-acetilgalaktozaminil-(N-acetilneuraminil) galaktozil-glukozil-keramid galaktoziltransferaza, UDP-galaktoza-GM2 gangliozidna galaktoziltransferaza, GM1-sintaza, UDP-galaktoza:N-acetil-D-galaktozaminil-(N-acetilneuraminil)-D-galaktozil-D-glukozil-N-acilsfingozin beta-1,3-D-galaktoziltransferaza, UDP-galaktoza:N-acetil-D-galaktozaminil-(N-acetilneuraminil)-D-galaktozil-(1->4)-beta-D-glukozil-N-acilsfingozin 3-beta-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:N-acetil-D-galaktozaminil-(N-acetilneuraminil)-D-galaktozil-(1->4)-beta-D-glukozil-N-acilsfingozin 3-beta-D-galaktoziltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-alfa-D--galaktoza + N-acetil-D-galaktozaminil-(N-acetilneuraminil)-D-galaktozil-(1->4)-beta-D-glukozil-N-acilsfingozin

\rightleftharpoons

UDP + D-galaktozil-(1->3)-beta-N-acetil-D-galaktozaminil-(N-acetilneuraminil)-D-galaktozil-D-glukozil-N-acilsfingozin

Supstrat je takođe poznat kao GM2.

Reference

↑ Basu, S., Kaufman, B. and Roseman, S. (1965). „Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase”. J. Biol. Chem. 240: 4115-4117. PMID 5842076.
↑ Yip, G.B. and Dain, J.A. (1970). „The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain”. Biochim. Biophys. Acta 206: 252-260. PMID 4987145.
↑ Yip, M.C.M. and Dain, J.A. (1970). „Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase”. Biochem. J. 118: 247-252. PMID 5484669.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Ganglioside+galactosyltransferase

[1] Basu, S., Kaufman, B. and Roseman, S. (1965). „Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase”. J. Biol. Chem. 240: 4115-4117. PMID 5842076.

[2] Yip, G.B. and Dain, J.A. (1970). „The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain”. Biochim. Biophys. Acta 206: 252-260. PMID 4987145.

[3] Yip, M.C.M. and Dain, J.A. (1970). „Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase”. Biochem. J. 118: 247-252. PMID 5484669.

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