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Furin
Identifikatori
EC broj	3.4.21.75
CAS broj	141760-45-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Furin (EC 3.4.21.75, prohormonska konvertaza, PACE, enzim razlaganja uparenih baznih aminokiselina, konvertujući enzim uparenih baznih aminokiselina, serinska proteinaza PACE, PC1, SPC3, proproteinska konvertaza) je enzim.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Oslobađanje maturisanih proteina iz njihovih proproteina razlaganjem -Arg-Xaa-Yaa-Arg- veza, gde Xaa može da bude bilo koja aminokiselina, dok je Yaa: Arg ili Lys. Oslobađa se albumin, komplementna komponenta C3 i von Vilebrandov faktor iz njihovih prekursora

Ova grupa peptidaza je strukturno i funkcionalno slična sa keksinom.

Reference

↑ Van de Ven, W.J.M., Voorberg, J., Fontijn, R., Pannekoek, H., van den Ouweland, A.M.W., van Duijnhoven, H.L.P., Roebroek, A.J.M. and Siezen, R.J. (1990). „Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes”. Mol. Biol. Rep. 14: 265-275. PMID 2094803.
↑ Van de Ven, W.J.M., Creemers, J.W.M. and Roebroek, A.J.M. (1991). „Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway”. Enzyme 45: 257-270. PMID 1843280.
↑ Hatsuzawa, K., Murakami, K. and Nakayama, K. (1992). „Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites”. J. Biochem. (Tokyo) 111: 296-301. PMID 1587790.
↑ Seidah, N.G. and Chrétien, M. (1992). „Proprotein and prohormone convertases of the subtilisin family: recent developments and future perspectives”. Trends Endocrinol. Metab. 3: 133-140.
↑ Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J. (1992). „The new enzymology of precursor processing endoproteases”. J. Biol. Chem. 267: 23435-23438. PMID 1429684.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Furin

[1] Van de Ven, W.J.M., Voorberg, J., Fontijn, R., Pannekoek, H., van den Ouweland, A.M.W., van Duijnhoven, H.L.P., Roebroek, A.J.M. and Siezen, R.J. (1990). „Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes”. Mol. Biol. Rep. 14: 265-275. PMID 2094803.

[2] Van de Ven, W.J.M., Creemers, J.W.M. and Roebroek, A.J.M. (1991). „Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway”. Enzyme 45: 257-270. PMID 1843280.

[3] Hatsuzawa, K., Murakami, K. and Nakayama, K. (1992). „Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites”. J. Biochem. (Tokyo) 111: 296-301. PMID 1587790.

[4] Seidah, N.G. and Chrétien, M. (1992). „Proprotein and prohormone convertases of the subtilisin family: recent developments and future perspectives”. Trends Endocrinol. Metab. 3: 133-140.

[5] Steiner, D.F., Smeekens, S.P., Ohagi, S. and Chan, S.J. (1992). „The new enzymology of precursor processing endoproteases”. J. Biol. Chem. 267: 23435-23438. PMID 1429684.

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