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Fumarat reduktaza (menahinon)
Identifikatori
EC broj	1.3.5.4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Fumarat reduktaza (menahinon) (EC 1.3.5.4, FRD, menahinol-fumaratna oksidoreduktaza, sukcinatna dehidrogenaza (menahinon)) je enzim sa sistematskim imenom sukcinat:menahinon oksidoreduktaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

sukcinat + menahinon

\rightleftharpoons

fumarat + menahinol

Ova reakcija je katalizovana u reverznom smeru. Enzim je deo anaerobnog lanca elektronskog transfera pojedinih bakterija. On omogućava fumaratu da služi kao terminalni elektronski akceptor.

Reference

↑ Iverson, T.M., Luna-Chavez, C., Cecchini, G. and Rees, D.C. (1999). „Structure of the Escherichia coli fumarate reductase respiratory complex”. Science 284: 1961-1966. PMID 10373108.
↑ Cecchini, G., Schroder, I., Gunsalus, R.P. and Maklashina, E. (2002). „Succinate dehydrogenase and fumarate reductase from Escherichia coli”. Biochim. Biophys. Acta 1553: 140-157. PMID 11803023.
↑ Iverson, T.M., Luna-Chavez, C., Croal, L.R., Cecchini, G. and Rees, D.C. (2002). „Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site”. J. Biol. Chem. 277: 16124-16130. PMID 11850430.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Fumarate+reductase+(menaquinone)

[1] Iverson, T.M., Luna-Chavez, C., Cecchini, G. and Rees, D.C. (1999). „Structure of the Escherichia coli fumarate reductase respiratory complex”. Science 284: 1961-1966. PMID 10373108.

[2] Cecchini, G., Schroder, I., Gunsalus, R.P. and Maklashina, E. (2002). „Succinate dehydrogenase and fumarate reductase from Escherichia coli”. Biochim. Biophys. Acta 1553: 140-157. PMID 11803023.

[3] Iverson, T.M., Luna-Chavez, C., Croal, L.R., Cecchini, G. and Rees, D.C. (2002). „Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site”. J. Biol. Chem. 277: 16124-16130. PMID 11850430.

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