PROFILPELAJAR.COM

Fosfoinozitidna fosfolipaza C
Identifikatori
EC broj	3.1.4.11
CAS broj	63551-76-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Fosfoinozitidna fosfolipaza C (EC 3.1.4.11, trifosfoinozitid fosfodiesteraza, fosfoinozitidaza C, 1-fosfatidilinozitol-4,5-bisfosfat fosfodiesteraza, monofosfatidilinozitol fosfodiesteraza, fosfatidilinozitol fosfolipaza C, PI-PLC, 1-fosfatidil-D-mio-inozitol-4,5-bisfosfat inozitoltrisfosfohidrolaza) je enzim sa sistematskim imenom 1-fosfatidil-1D-mio-inozitol-4,5-bisfosfat inozitoltrisfosfohidrolaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-fosfatidil-1D-mio-inozitol 4,5-bisfosfat + H₂O

\rightleftharpoons

1D-mio-inozitol 1,4,5-trisfosfat + diacilglicerol

Ovi enzimi formiraju ciklične fosfatne Ins(ciklični1,2)P(4,5)P2 kao i Ins(1,4,5)P3. On deluju na fosfatidilinozitol.

Reference

↑ Downes, C.P. and Michell, R.H. (1981). „The polyphosphoinositide phosphodiesterase of erythrocyte membranes”. Biochem. J. 198: 133-140. PMID 6275838.
↑ Thompson, W. and Dawson, R.M.C. (1964). „The triphosphoinositide phosphodiesterase of brain tissue”. Biochem. J. 91: 237-243.
↑ Rhee, S.G. and Bae, Y.S. (1997). „Regulation of phosphoinositide-specific phospholipase C isozymes”. J. Biol. Chem. 272: 15045-15048. PMID 9182519.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Phosphoinositide+phospholipase+C

[1] Downes, C.P. and Michell, R.H. (1981). „The polyphosphoinositide phosphodiesterase of erythrocyte membranes”. Biochem. J. 198: 133-140. PMID 6275838.

[2] Thompson, W. and Dawson, R.M.C. (1964). „The triphosphoinositide phosphodiesterase of brain tissue”. Biochem. J. 91: 237-243.

[3] Rhee, S.G. and Bae, Y.S. (1997). „Regulation of phosphoinositide-specific phospholipase C isozymes”. J. Biol. Chem. 272: 15045-15048. PMID 9182519.

[1]

[2]

[3]