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Fosfo-N-acetilmuramoil-pentapeptid-transferaza
Identifikatori
EC broj	2.7.8.13
CAS broj	9068-50-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Fosfo-N-acetilmuramoil-pentapeptid-transferaza (EC 2.7.8.13, MraY transferaza, UDP-MurNAc-L-Ala-D-gama-Glu-L-Lys-D-Ala-D-Ala:C⁵⁵-izoprenoid alkoholna transferaza, UDP-MurNAc-Ala-gamaDGlu-Lys-DAla-DAla:undekaprenilfosfat transferaza, fosfo-N-acetilmuramoil pentapeptidna translokaza, fosfo-MurNAc-pentapeptidna transferaza, fosfo-NAc-muramoil-pentapeptidna translokaza (UMP), fosfoacetilmuramoilpentapeptidna translokaza, fosfoacetilmuramoilpentapeptidtransferaza) je enzim sa sistematskim imenom UDP-MurAc(oil-L-Ala-gama-D-Glu-L-Lis-D-Ala-D-Ala):undekaprenil-fosfat fosfo-N-acetilmuramoil-pentapeptid-transferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-Mur2Ac(oil-L-Ala-gama-D-Glu-L-Lys-D-Ala-D-Ala) + undekaprenil fosfat

\rightleftharpoons

UMP + Mur2Ac(oil-L-Ala-gama-D-Glu-L-Lys-D-Ala-D-Ala)-difosfoundekaprenol

Kod Gram-negativnih i pojedinih Gram-pozitivnih organizama L-lizin je zamenjen meso-2,6-diaminoheptanedioatom.

Reference

↑ Heydanek, M.G., Jr. and Neuhaus, F.C. (1969). „The initial stage in peptidoglycan synthesis. IV. Solubilization of phospho-N-acetylmuramyl-pentapeptide translocase”. Biochemistry 8: 1474-1481. PMID 5805290.
↑ Higashi, Y., Strominger, J.L. and Sweeley, C.C. (1967). „Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C₅₅ isoprenoid alcohol”. Proc. Natl. Acad. Sci. USA 57: 1878-1884. PMID 5231417.
↑ Struve, W.G., Sinha, R.K. and Neuhaus, F.C. (1966). „On the initial stage in peptidoglycan synthesis. Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate)”. Biochemistry 5: 82-93. PMID 5938956.
↑ van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503-519. PMID 11699883.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Phospho-N-acetylmuramoyl-pentapeptide-transferase

[1] Heydanek, M.G., Jr. and Neuhaus, F.C. (1969). „The initial stage in peptidoglycan synthesis. IV. Solubilization of phospho-N-acetylmuramyl-pentapeptide translocase”. Biochemistry 8: 1474-1481. PMID 5805290.

[2] Higashi, Y., Strominger, J.L. and Sweeley, C.C. (1967). „Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C₅₅ isoprenoid alcohol”. Proc. Natl. Acad. Sci. USA 57: 1878-1884. PMID 5231417.

[3] Struve, W.G., Sinha, R.K. and Neuhaus, F.C. (1966). „On the initial stage in peptidoglycan synthesis. Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate)”. Biochemistry 5: 82-93. PMID 5938956.

[4] van Heijenoort, J. (2001). „Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18: 503-519. PMID 11699883.

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