PROFILPELAJAR.COM

Fosfatidilinozitol-4,5-bisfosfatna 4-fosfataza
Identifikatori
EC broj	3.1.3.78
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Fosfatidilinozitol-4,5-bisfosfatna 4-fosfataza (EC 3.1.3.78, fosfatidilinozitol-4,5-bisfosfat 4-fosfataza I, fosfatidilinozitol-4,5-bisfosfat 4-fosfataza II, tip I PtdIns-4,5-P2 4-Ptaza, tip II PtdIns-4,5-P2 4-Ptaza, IpgD, PtdIns-4,5-P2 4-fosfataza tip I, PtdIns-4,5-P2 4-fosfataza tip II, tip I fosfatidilinozitol-4,5-bisfosfat 4-fosfataza, tip 1 4-fosfataza) je enzim sa sistematskim imenom 1-fosfatidil-1D-mio-inozitol-4,5-bisfosfat 4-fosfohidrolaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-fosfatidil-1D-mio-inozitol 4,5-bisfosfat + H₂O

\rightleftharpoons

1-fosfatidil-1D-mio-inozitol 5-fosfat + fosfat

U ćelijama sisara postoje dva puta za degradaciju 1-fosfatidil-1D-mio-inozitol 4,5-bisfosfata [PtdIns(4,5)P2]. Jedan je katalizovan ovim enzimom, a drugi enzimom EC 3.1.3.36, fosfoinozitid 5-fosfatazom.

Reference

↑ Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B. (2002). „Conversion of PtdIns(4,5)P₂ into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology”. EMBO J. 21: 5069-5078. PMID 12356723.
↑ Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W. (2005). „The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases”. Proc. Natl. Acad. Sci. USA 102: 18854-18859. PMID 16365287.
↑ Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W. (2007). „Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis”. Proc. Natl. Acad. Sci. USA 104: 16834-16839. PMID 17940011.
↑ Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S. (2007). „Alteration of epithelial structure and function associated with PtdIns(4,5)P₂ degradation by a bacterial phosphatase”. J. Gen. Physiol. 129: 267-283. PMID 17389247.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Phosphatidylinositol-4,5-bisphosphate+4-phosphatase

[1] Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B. (2002). „Conversion of PtdIns(4,5)P₂ into PtdIns(5)P by the S. flexneri effector IpgD reorganizes host cell morphology”. EMBO J. 21: 5069-5078. PMID 12356723.

[2] Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W. (2005). „The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases”. Proc. Natl. Acad. Sci. USA 102: 18854-18859. PMID 16365287.

[3] Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W. (2007). „Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis”. Proc. Natl. Acad. Sci. USA 104: 16834-16839. PMID 17940011.

[4] Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S. (2007). „Alteration of epithelial structure and function associated with PtdIns(4,5)P₂ degradation by a bacterial phosphatase”. J. Gen. Physiol. 129: 267-283. PMID 17389247.

[1]

[2]

[3]

[4]