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Fosfatidilinozitol-3,4-bisfosfatna 4-fosfataza
Identifikatori
EC broj	3.1.3.66
CAS broj	123644-80-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Fosfatidilinozitol-3,4-bisfosfatna 4-fosfataza (EC 3.1.3.66, inozitol-3,4-bisfosfat 4-fosfataza, D-mio-inozitol-3,4-bisfosfat 4-fosfohidrolaza, fosfoinositide 4-fosfataza, inozitol polifosfat 4-fosfataza, inozitol polifosfat 4-fosfataza tip II) je enzim sa sistematskim imenom 1-fosfatidil-1D-mio-inozitol-3,4-bisfosfat 4-fosfohidrolaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

1-fosfatidil-mio-inozitol 3,4-bisfosfat + H₂O

\rightleftharpoons

1-fosfatidil-1D-mio-inozitol 3-fosfat + fosfat

Ovaj enzim ne zavisi od Mg²⁺ jona.

Reference

↑ Howell, S., Barnaby, R.J., Rowe, T., Ragan, C.I. and Gee, N.S. (1989). „Evidence for at least four different inositol bisphosphatases in bovine brain”. Eur. J. Biochem. 183: 169-172. PMID 2546770.
↑ Norris, F.A., Auethavekiat, V. and Majerus, P.W. (1995). „The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase”. J. Biol. Chem. 270: 16128-16133. PMID 7608176.
↑ Norris, F.A., Atkins, R.C. and Majerus, P.W. (1997). „The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family”. J. Biol. Chem. 272: 23859-23864. PMID 9295334.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Phosphatidylinositol-3,4-bisphosphate+4-phosphatase

[1] Howell, S., Barnaby, R.J., Rowe, T., Ragan, C.I. and Gee, N.S. (1989). „Evidence for at least four different inositol bisphosphatases in bovine brain”. Eur. J. Biochem. 183: 169-172. PMID 2546770.

[2] Norris, F.A., Auethavekiat, V. and Majerus, P.W. (1995). „The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase”. J. Biol. Chem. 270: 16128-16133. PMID 7608176.

[3] Norris, F.A., Atkins, R.C. and Majerus, P.W. (1997). „The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family”. J. Biol. Chem. 272: 23859-23864. PMID 9295334.

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