Ovaj gen kodira fosfoprotein, koji je lociran u vanjski i unutarnji segmentima štapićastih ćelija mrežnjače. Ovaj protein može da sudeluje u regulaciji vizuelne fototransdukcije ili u integraciji fotoreceptorskog metabolizama. On modulira fototransdukcionu kaskadu putem interakcije sa beta i gama podjedinicama retinalnog G-proteina transducina. Vezivanjem za te dve podjedinice transducin će ostati vezan za alfa podjedinicu duže. To produžava trajanje vizuelne pobude.
Ovaj gen je potencijalni kandidat za retinitis pigmentosa i Ušerov sindrom tipa II. Alternativno splajsovane transkriptne varijante koje kodiraju različite izoforme su bile identifikovane.[1]
Watanabe Y, Kawasaki K, Miki N, Kuo CH (1990). „Isolation and analysis of the human MEKA gene encoding a retina-specific protein.”. Biochem. Biophys. Res. Commun.170 (2): 951–6. DOI:10.1016/0006-291X(90)92183-Z. PMID2383274.
Lee RH, Brown BM, Lolley RN (1990). „Protein kinase A phosphorylates retinal phosducin on serine 73 in situ.”. J. Biol. Chem.265 (26): 15860–6. PMID2394752.
Hawes BE, Touhara K, Kurose H, et al. (1994). „Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling.”. J. Biol. Chem.269 (47): 29825–30. PMID7961975.
Abe T, Kikuchi T, Shinohara T (1994). „The sequence of the human phosducin gene (PDC) and its 5'-flanking region.”. Genomics19 (2): 369–72. DOI:10.1006/geno.1994.1072. PMID8188267.
Sparkes RS, Lee RH, Shinohara T, et al. (1994). „Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization.”. Genomics18 (2): 426–8. DOI:10.1006/geno.1993.1490. PMID8288249.
Ding C, Li X, Griffin CA, et al. (1994). „The gene for human phosducin (PDC), a soluble protein that binds G-protein beta gamma dimers, maps to 1q25-q31.1.”. Genomics18 (2): 457–9. DOI:10.1006/geno.1993.1501. PMID8288259.
Boekhoff I, Touhara K, Danner S, et al. (1997). „Phosducin, potential role in modulation of olfactory signaling.”. J. Biol. Chem.272 (7): 4606–12. DOI:10.1074/jbc.272.7.4606. PMID9020189.
Barhite S, Thibault C, Miles MF (1998). „Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1.”. Biochim. Biophys. Acta1402 (1): 95–101. DOI:10.1016/S0167-4889(97)00141-9. PMID9551090.
Zhu X, Craft CM (1998). „Interaction of phosducin and phosducin isoforms with a 26S proteasomal subunit, SUG1.”. Mol. Vis.4: 13. PMID9701609.
Craft CM, Xu J, Slepak VZ, et al. (1998). „PhLPs and PhLOPs in the phosducin family of G beta gamma binding proteins.”. Biochemistry37 (45): 15758–72. DOI:10.1021/bi980921a. PMID9843381.
Carpten JD, Makalowska I, Robbins CM, et al. (2000). „A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region.”. Genomics64 (1): 1–14. DOI:10.1006/geno.1999.6051. PMID10708513.
Zhu X, Craft CM (2000). „The carboxyl terminal domain of phosducin functions as a transcriptional activator.”. Biochem. Biophys. Res. Commun.270 (2): 504–9. DOI:10.1006/bbrc.2000.2414. PMID10753654.
Ruiz-Gómez A, Humrich J, Murga C, et al. (2000). „Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.”. J. Biol. Chem.275 (38): 29724–30. DOI:10.1074/jbc.M001864200. PMID10884381.
Thulin CD, Savage JR, McLaughlin JN, et al. (2001). „Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.”. J. Biol. Chem.276 (26): 23805–15. DOI:10.1074/jbc.M101482200. PMID11331285.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). „Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.”. Mol. Vis.8: 196–204. PMID12107411.