Flavivirin

Flavivirin
Identifikatori
EC broj 3.4.21.91
CAS broj 154215-26-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Flavivirin (EC 3.4.21.91, proteaza virusa žute groznice (flavi virusa), NS2B-3 proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Selectivna hidroliza -Xaa-Xaa-Yaa- veza u kojima Xaa može da bude bilo Arg ili Lys i Yaa može da bude bilo Ser ili Ala

Ovaj enzim je poznat iz klasičnih flavivirusa (žuta groznica, denga groznica).

Reference

  1. ↑ Chambers, T.J., Hahn, C.S., Galler, R. and Rice, C.M. (1990). „Flavivirus genome organization, expression, and replication”. Annu. Rev. Microbiol. 44: 649-688. PMID 2174669. 
  2. ↑ Cahour, A., Falgout, B. and Lai, C.-J. (1992). „Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease”. J. Virol. 66: 1535-1542. PMID 1531368. 
  3. ↑ Lin, C., Amberg, S.M., Chambers, T.J. and Rice, C.M. (1993). „Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site”. J. Virol. 67: 2327-2335. PMID 8445732. 

Literatura

Vanjske veze