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Fenilacetil-KoA 1,2-epoksidaza
Identifikatori
EC broj	1.14.13.149
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Fenilacetil-KoA 1,2-epoksidaza (EC 1.14.13.149, ring 1,2-fenilacetil-KoA epoksidaza, fenilacetil-KoA monooksigenaza, PaaAC, PaaABC(D)E) je enzim sa sistematskim imenom fenilacetil-KoA:kiseonik oksidoreduktaza (1,2-epoksidacija).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

fenilacetil-KoA + NADPH + H⁺ + O₂

\rightleftharpoons

2-(1,2-epoksi-1,2-dihidrofenil)acetil-KoA + NADP⁺ + H₂O

Ovaj enzim učestvuje u aerobnom katabolizmu fenilacetata kod Escherichia coli i Pseudomonas putida.

Reference

↑ Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. (2010). „Bacterial phenylalanine and phenylacetate catabolic pathway revealed”. Proc. Natl. Acad. Sci. USA 107: 14390-14395. PMID 20660314.
↑ Grishin, A.M., Ajamian, E., Zhang, L. and Cygler, M. (2010). „Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66: 1045-1049. PMID 20823522.
↑ Grishin, A.M., Ajamian, E., Tao, L., Zhang, L., Menard, R. and Cygler, M. (2011). „Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex”. J. Biol. Chem. 286: 10735-10743. PMID 21247899.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Phenylacetyl-CoA+1,2-epoxidase

[1] Teufel, R., Mascaraque, V., Ismail, W., Voss, M., Perera, J., Eisenreich, W., Haehnel, W. and Fuchs, G. (2010). „Bacterial phenylalanine and phenylacetate catabolic pathway revealed”. Proc. Natl. Acad. Sci. USA 107: 14390-14395. PMID 20660314.

[2] Grishin, A.M., Ajamian, E., Zhang, L. and Cygler, M. (2010). „Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66: 1045-1049. PMID 20823522.

[3] Grishin, A.M., Ajamian, E., Tao, L., Zhang, L., Menard, R. and Cygler, M. (2011). „Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex”. J. Biol. Chem. 286: 10735-10743. PMID 21247899.

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