FMN reduktaza (NADPH)

FMN reduktaza (NADPH)
Identifikatori
EC broj 1.5.1.38
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

FMN reduktaza (NADPH) (EC 1.5.1.38, FRP, flavinska reduktaza P, SsuE) je enzim sa sistematskim imenom FMNH2:NADP+ oksidoreduktaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

FMNH2 + NADP+ FMN + NADPH + H+

Enzimi iz bioluminescentih bakterija sadrže FMN, za razliku od enzima iz Escherichia coli.

Reference

  1. ↑ Gerlo, E. and Charlier, J. (1975). „Identification of NADH-specific and NADPH-specific FMN reductases in Beneckea harveyi”. Eur. J. Biochem. 57: 461-467. PMID 1175652. 
  2. ↑ Jablonski, E. and DeLuca, M. (1977). „Purification and properties of the NADH and NADPH specific FMN oxidoreductases from Beneckea harveyi”. Biochemistry 16: 2932-2936. PMID 880288. 
  3. ↑ Jablonski, E. and DeLuca, M. (1978). „Studies of the control of luminescence in Beneckea harveyi: properties of the NADH and NADPH:FMN oxidoreductases”. Biochemistry 17: 672-678. PMID 23827. 
  4. ↑ Lei, B., Liu, M., Huang, S. and Tu, S.C. (1994). „Vibrio harveyi NADPH-flavin oxidoreductase: cloning, sequencing and overexpression of the gene and purification and characterization of the cloned enzyme”. J. Bacteriol. 176: 3552-3558. PMID 8206832. 
  5. ↑ Tanner, J.J., Lei, B., Tu, S.C. and Krause, K.L. (1996). „Flavin reductase P: structure of a dimeric enzyme that reduces flavin”. Biochemistry 35: 13531-13539. PMID 8885832. 
  6. ↑ Liu, M., Lei, B., Ding, Q., Lee, J.C. and Tu, S.C. (1997). „Vibrio harveyi NADPH:FMN oxidoreductase: preparation and characterization of the apoenzyme and monomer-dimer equilibrium”. Arch. Biochem. Biophys. 337: 89-95. PMID 8990272. 
  7. ↑ Lei, B. and Tu, S.C. (1998). „Mechanism of reduced flavin transfer from Vibrio harveyi NADPH-FMN oxidoreductase to luciferase”. Biochemistry 37: 14623-14629. PMID 9772191. 
  8. ↑ Eichhorn, E., van der Ploeg, J.R. and Leisinger, T. (1999). „Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli”. J. Biol. Chem. 274: 26639-26646. PMID 10480865. 

Literatura

Vanjske veze