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Dugolančani enoil-KoA reduktaza
Identifikatori
EC broj	1.3.1.93
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Dugolančani enoil-KoA reduktaza (EC 1.3.1.93, TSC13 (gen), CER10 (gen)) je enzim sa sistematskim imenom dugolančani acil-KoA:NADP⁺ oksidoreduktaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

dugolančani acil-KoA + NADP⁺

\rightleftharpoons

dugolančani trans-2,3-dehidroacil-KoA + NADPH + H⁺

Ovaj enzim je četvrta komponenta elongaze, mikrozomalnog proteinskog kompleksa koji je odgovoran za produžavanje palmitoila KoA i stearoila KoA (kao i njihovih modifikovanih formi) do dugolančanih acil KoA molekula.

Reference

↑ Kohlwein, S.D., Eder, S., Oh, C.S., Martin, C.E., Gable, K., Bacikova, D. and Dunn, T. (2001). „Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae”. Mol. Cell Biol. 21: 109-125. PMID 11113186.
↑ Gable, K., Garton, S., Napier, J.A. and Dunn, T.M. (2004). „Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system”. J. Exp. Bot. 55: 543-545. PMID 14673020.
↑ Kvam, E., Gable, K., Dunn, T.M. and Goldfarb, D.S. (2005). „Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles”. Mol. Biol. Cell 16: 3987-3998. PMID 15958487.
↑ Zheng, H., Rowland, O. and Kunst, L. (2005). „Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis”. Plant Cell 17: 1467-1481. PMID 15829606.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Very-long-chain+enoyl-CoA+reductase

[1] Kohlwein, S.D., Eder, S., Oh, C.S., Martin, C.E., Gable, K., Bacikova, D. and Dunn, T. (2001). „Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae”. Mol. Cell Biol. 21: 109-125. PMID 11113186.

[2] Gable, K., Garton, S., Napier, J.A. and Dunn, T.M. (2004). „Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system”. J. Exp. Bot. 55: 543-545. PMID 14673020.

[3] Kvam, E., Gable, K., Dunn, T.M. and Goldfarb, D.S. (2005). „Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles”. Mol. Biol. Cell 16: 3987-3998. PMID 15958487.

[4] Zheng, H., Rowland, O. and Kunst, L. (2005). „Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis”. Plant Cell 17: 1467-1481. PMID 15829606.

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