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Dugolančana-masna-acil-KoA reduktaza
Identifikatori
EC broj	1.2.1.50
CAS broj	50936-56-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Dugolančana-masna-acil-KoA reduktaza (EC 1.2.1.50, acil-KoA reduktaza, acil koenzim A reduktaza) je enzim sa sistematskim imenom dugolančani aldehid:NADP⁺ oksidoreduktaza (formira acil-KoA).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

dugolančani aldehid + KoA + NADP⁺

\rightleftharpoons

dugolančani acil-KoA + NADPH + H⁺

Zajedno sa EC 6.2.1.19, ligazom dugolančane masne-kiseline---luciferin-komponente, formira reduktazni sistem masnih kiselina koji formura supstrat za EC 1.14.14.3, alkanalnu monooksigenazu (FMN-vezanu). Ona je deo bakterijskog luciferaznog sistema.

Reference

↑ Riendeau, D., Rodrigues, A. and Meighen, E. (1982). „Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex”. J. Biol. Chem. 257: 6908-6915. PMID 7085612.
↑ Wall, L. and Meighen, E.A. (1986). „Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum”. Biochemistry 25: 4315-4321.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Long-chain-fatty-acyl-CoA+reductase

[1] Riendeau, D., Rodrigues, A. and Meighen, E. (1982). „Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex”. J. Biol. Chem. 257: 6908-6915. PMID 7085612.

[2] Wall, L. and Meighen, E.A. (1986). „Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum”. Biochemistry 25: 4315-4321.

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