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Digalaktozildiacilglicerol sintaza
Identifikatori
EC broj	2.4.1.241
CAS broj	69913-00-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Digalaktozildiacilglicerol sintaza (EC 2.4.1.241, DGD1, DGD2, DGDG sintaza, UDP-galaktoza-zavisna DGDG sintaza, UDP-galaktoza-zavisna digalaktozildiacilglicerol sintaza, UDP-galaktoza:MGDG galaktoziltransferaza, UDP-galaktoza:3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol 6-alfa-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol 6-alfa-galaktoziltransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-alfa-D-galaktoza + 3-(beta-D-galaktozil)-1,2-diacil-sn-glicerol

\rightleftharpoons

UDP + 3-[alfa-D-galaktozil-(1->6)-beta-D-galaktozil]-1,2-diacil-sn-glicerol

Za dejstvo ovog enzima je neophodan Mg²⁺. Diacilglicerol ne može da služi kao akceptorski molekule za galaktozilaciju u reakciji katalizovanoj enzimom EC 2.4.1.46, monogalaktozildiacilglicerol sintaza.

Reference

↑ Kelly, A.A. and Dörmann, P. (2002). „DGD2, an Arabidopsis gene encoding a UDP-galactose-dependent digalactosyldiacylglycerol synthase is expressed during growth under phosphate-limiting conditions”. J. Biol. Chem. 277: 1166-1173. PMID 11696551.
↑ Härtel, H., Dörmann, P. and Benning, C. (2000). „DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in Arabidopsis”. Proc. Natl. Acad. Sci. USA 97: 10649-10654. PMID 10973486.
↑ Kelly, A.A., Froehlich, J.E. and Dörmann, P. (2003). „Disruption of the two digalactosyldiacylglycerol synthase genes DGD1 and DGD2 in Arabidopsis reveals the existence of an additional enzyme of galactolipid synthesis”. Plant Cell 15: 2694-2706. PMID 14600212.
↑ Benning, C. and Ohta, H. (2005). „Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants”. J. Biol. Chem. 280: 2397-2400. PMID 15590685.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Digalactosyldiacylglycerol+synthase

[1] Kelly, A.A. and Dörmann, P. (2002). „DGD2, an Arabidopsis gene encoding a UDP-galactose-dependent digalactosyldiacylglycerol synthase is expressed during growth under phosphate-limiting conditions”. J. Biol. Chem. 277: 1166-1173. PMID 11696551.

[2] Härtel, H., Dörmann, P. and Benning, C. (2000). „DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in Arabidopsis”. Proc. Natl. Acad. Sci. USA 97: 10649-10654. PMID 10973486.

[3] Kelly, A.A., Froehlich, J.E. and Dörmann, P. (2003). „Disruption of the two digalactosyldiacylglycerol synthase genes DGD1 and DGD2 in Arabidopsis reveals the existence of an additional enzyme of galactolipid synthesis”. Plant Cell 15: 2694-2706. PMID 14600212.

[4] Benning, C. and Ohta, H. (2005). „Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants”. J. Biol. Chem. 280: 2397-2400. PMID 15590685.

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