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Dezoksicitidin kinaza
Identifikatori
EC broj	2.7.1.74
CAS broj	9039-45-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Dezoksicitidin kinaza (EC 2.7.1.74, dezoksicitidinska kinaza (fosforilacija), 2'-dezoksicitidinska kinaza, Ara-C kinaza, arabinofuranozilcitozinska kinaza, dezoksicitidin-citidinska kinaza) je enzim sa sistematskim imenom NTP:dezoksicitidin 5'-fosfotransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

NTP + dezoksicitidin

\rightleftharpoons

NDP + dCMP

Citozin arabinozid može da deluje kao akceptor. Svi prirodni nukleozid trifosfati (izuzev dCTP) mogu da budu donori.

Reference

↑ Durham, J.P. and Ives, D.H. (1970). „Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme”. J. Biol. Chem. 245: 2276-2284. PMID 5442271.
↑ Ives, D.H. and Durham, J.P. (1970). „Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme”. J. Biol. Chem. 245: 2285-2294. PMID 5462538.
↑ Kessel, D. (1968). „Properties of deoxycytidine kinase partially purified from L1210 cells”. J. Biol. Chem. 243: 4739-4744. PMID 5687717.
↑ Momparler, R.L. and Fischer, G.A. (1968). „Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside”. J. Biol. Chem. 243: 4298-4304. PMID 5684726.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Deoxycytidine+kinase

[1] Durham, J.P. and Ives, D.H. (1970). „Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme”. J. Biol. Chem. 245: 2276-2284. PMID 5442271.

[2] Ives, D.H. and Durham, J.P. (1970). „Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme”. J. Biol. Chem. 245: 2285-2294. PMID 5462538.

[3] Kessel, D. (1968). „Properties of deoxycytidine kinase partially purified from L1210 cells”. J. Biol. Chem. 243: 4739-4744. PMID 5687717.

[4] Momparler, R.L. and Fischer, G.A. (1968). „Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside”. J. Biol. Chem. 243: 4298-4304. PMID 5684726.

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