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Dermatan 4-sulfotransferaza
Identifikatori
EC broj	2.8.2.35
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Dermatan 4-sulfotransferaza (EC 2.8.2.35, dermatan-specifična N-acetilgalaktozamin 4-O-sulfotransferaza, dermatan-4-sulfotransferaza-1, dermatan-4-sulfotransferaza 1, D4ST-1, dermatan N-acetilgalaktozamin 4-O-sulfotransferaza, CHST14 protein, CHST14) je enzim sa sistematskim imenom 3'-fosfo-5'-adenilil sulfat:(dermatan)-N-acetil-D-galaktozamin 4-sulfotransferaza.^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

3'-fosfo-5'-adenilil sulfat + [dermatan]-N-acetil-D-galaktozamin

\rightleftharpoons

adenozin 3',5'-bisfosfat + [dermatan]-4-O-sulfo-N-acetil-D-galaktozamin

Sulfacija se odvija u 4-pozicija N-acetil-D-galaktozaminskih ostataka dermatana.

Reference

↑ Evers, M.R., Xia, G., Kang, H.G., Schachner, M. and Baenziger, J.U. (2001). „Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase”. J. Biol. Chem. 276: 36344-36353. PMID 11470797.
↑ Mikami, T., Mizumoto, S., Kago, N., Kitagawa, H. and Sugahara, K. (2003). „Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis”. J. Biol. Chem. 278: 36115-36127. PMID 12847091.
↑ Pacheco, B., Maccarana, M. and Malmstrom, A. (2009). „Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate”. Glycobiology 19: 1197-1203. PMID 19661164.
↑ Mitsunaga, C., Mikami, T., Mizumoto, S., Fukuda, J. and Sugahara, K. (2006). „Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases”. J. Biol. Chem. 281: 18942-18952. PMID 16702220.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Dermatan+4-sulfotransferase

[1] Evers, M.R., Xia, G., Kang, H.G., Schachner, M. and Baenziger, J.U. (2001). „Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase”. J. Biol. Chem. 276: 36344-36353. PMID 11470797.

[2] Mikami, T., Mizumoto, S., Kago, N., Kitagawa, H. and Sugahara, K. (2003). „Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis”. J. Biol. Chem. 278: 36115-36127. PMID 12847091.

[3] Pacheco, B., Maccarana, M. and Malmstrom, A. (2009). „Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate”. Glycobiology 19: 1197-1203. PMID 19661164.

[4] Mitsunaga, C., Mikami, T., Mizumoto, S., Fukuda, J. and Sugahara, K. (2006). „Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases”. J. Biol. Chem. 281: 18942-18952. PMID 16702220.

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