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Deacetilcefalosporin-C acetiltransferaza
Identifikatori
EC broj	2.3.1.175
CAS broj	57827-76-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Deacetilcefalosporin-C acetiltransferaza (EC 2.3.1.175, acetil-KoA:deacetilcefalosporin-C acetiltransferaza, DAC acetiltransferaza, cefG, deacetilcefalosporin C acetiltransferaza, acetil koenzim A:DAC acetiltransferaza, acetil-KoA:DAC acetiltransferaza, CPC acetilhidrolaza, acetil-KoA:DAC O-acetiltransferaza, DAC-AT) je enzim sa sistematskim imenom acetil-KoA:deacetilcefalosporin-C O-acetiltransferaza.^[1]^[2]^[3]^[4]^[5]^[6] Ovaj enzim katalizuje sledeću hemijsku reakciju

acetil-KoA + deacetilcefalosporin C

\rightleftharpoons

KoA + cefalosporin C

Ovaj enzim katalizuje finalni korak u biosintezi cefalosporina C.

Reference

↑ Matsuyama, K., Matsumoto, H., Matsuda, A., Sugiura, H., Komatsu, K. and Ichikawa, S. (1992). „Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum”. Biosci. Biotechnol. Biochem. 56: 1410-1412. PMID 1368946.
↑ Gutiérrez, S., Velasco, J., Fernandez, F.J. and Martín, J.F. (1992). „The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase”. J. Bacteriol. 174: 3056-3064. PMID 1569032.
↑ Matsuda, A., Sugiura, H., Matsuyama, K., Matsumoto, H., Ichikawa, S. and Komatsu, K. (1992). „Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C O-acetyltransferase from Acremonium chrysogenum”. Biochem. Biophys. Res. Commun. 186: 40-46. PMID 1632779.
↑ Gutiérrez, S., Velasco, J., Marcos, A.T., Fernández, F.J., Fierro, F., Barredo, J.L., Díez, B. and Martín, J.F. (1997). „Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum”. Appl. Microbiol. Biotechnol. 48: 606-614. PMID 9421924.
↑ Velasco, J., Gutierrez, S., Campoy, S. and Martin, J.F. (1999). „Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits”. Biochem. J. 337: 379-385. PMID 9895280.
↑ Martín, J.F., Gutiérrez, S., Fernández, F.J., Velasco, J., Fierro, F., Marcos, A.T. and Kosalkova, K. (1994). „Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins”. Antonie Van Leeuwenhoek 65: 227-243. PMID 7847890.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Deacetylcephalosporin-C+acetyltransferase

[1] Matsuyama, K., Matsumoto, H., Matsuda, A., Sugiura, H., Komatsu, K. and Ichikawa, S. (1992). „Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum”. Biosci. Biotechnol. Biochem. 56: 1410-1412. PMID 1368946.

[2] Gutiérrez, S., Velasco, J., Fernandez, F.J. and Martín, J.F. (1992). „The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase”. J. Bacteriol. 174: 3056-3064. PMID 1569032.

[3] Matsuda, A., Sugiura, H., Matsuyama, K., Matsumoto, H., Ichikawa, S. and Komatsu, K. (1992). „Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C O-acetyltransferase from Acremonium chrysogenum”. Biochem. Biophys. Res. Commun. 186: 40-46. PMID 1632779.

[4] Gutiérrez, S., Velasco, J., Marcos, A.T., Fernández, F.J., Fierro, F., Barredo, J.L., Díez, B. and Martín, J.F. (1997). „Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum”. Appl. Microbiol. Biotechnol. 48: 606-614. PMID 9421924.

[5] Velasco, J., Gutierrez, S., Campoy, S. and Martin, J.F. (1999). „Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits”. Biochem. J. 337: 379-385. PMID 9895280.

[6] Martín, J.F., Gutiérrez, S., Fernández, F.J., Velasco, J., Fierro, F., Marcos, A.T. and Kosalkova, K. (1994). „Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins”. Antonie Van Leeuwenhoek 65: 227-243. PMID 7847890.

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