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D-alanin-poli(fosforibitol) ligaza
Identifikatori
EC broj	6.1.1.13
CAS broj	9023-65-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

D-alanin-poli(fosforibitol) ligaza (EC 6.1.1.13, D-alanil-poli(fosforibitol) sintetaza, D-alanin: membransko akceptorska ligaza, D-alanin-D-alanil nosilac proteinska ligaza, D-alanin-membranska akceptorska ligaza, D-alanin-aktivirajući enzim) je enzim sa sistematskim imenom D-alanin:poli(fosforibitol) ligaza (formira AMP).^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + D-alanin + poli(ribitol fosfat)

\rightleftharpoons

AMP + difosfat + O-D-alanil-poli(ribitol fosfat)

Tioestarska veza se formira tranzijentno između D-alanina i sulfhidrilne grupe 4'-fosfopanteteinske prostetičke grupe D-alanil proteinskog nosioca tokom aktivacije alanina.

Reference

↑ Baddiley, J. and Neuhaus, F.C. (1960). „The enzymic activation of D-alanine”. Biochem. J. 75: 579-579. PMID 13795638.
↑ Reusch, V.M. and Neuhaus, F.C. (1971). „D-Alanine:membrane acceptor ligase from Lactobacillus casei”. J. Biol. Chem. 246: 6136-6143. PMID 4399593.
↑ Perego, M., Glaser, P., Minutello, A., Strauch, M.A., Leopold, K. and Fischer, W. (1995). „Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis”. J. Biol. Chem. 270: 15598-15606. PMID 7797557.
↑ Heaton, M.P. and Neuhaus, F.C. (1994). „Role of D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid”. J. Bacteriol. 176: 681-690. PMID 8300523.
↑ Debabov, D.V., Heaton, M.P., Zhang, Q., Stewart, K.D., Lambalot, R.H. and Neuhaus, F.C. (1996). „The D-alanyl carrier protein in Lactobacillus casei: cloning, sequencing and expression of dltC”. J. Bacteriol. 178: 3869-3876. PMID 8682792.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH D-alanine---poly(phosphoribitol)+ligase

[1] Baddiley, J. and Neuhaus, F.C. (1960). „The enzymic activation of D-alanine”. Biochem. J. 75: 579-579. PMID 13795638.

[2] Reusch, V.M. and Neuhaus, F.C. (1971). „D-Alanine:membrane acceptor ligase from Lactobacillus casei”. J. Biol. Chem. 246: 6136-6143. PMID 4399593.

[3] Perego, M., Glaser, P., Minutello, A., Strauch, M.A., Leopold, K. and Fischer, W. (1995). „Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis”. J. Biol. Chem. 270: 15598-15606. PMID 7797557.

[4] Heaton, M.P. and Neuhaus, F.C. (1994). „Role of D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid”. J. Bacteriol. 176: 681-690. PMID 8300523.

[5] Debabov, D.V., Heaton, M.P., Zhang, Q., Stewart, K.D., Lambalot, R.H. and Neuhaus, F.C. (1996). „The D-alanyl carrier protein in Lactobacillus casei: cloning, sequencing and expression of dltC”. J. Bacteriol. 178: 3869-3876. PMID 8682792.

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