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Cistein dioksigenaza, tip I
Identifikatori
Simbol	CDO1
Entrez	1036
Hugo	1795
OMIM	603943
RefSek	NM_001801
UniProt	Q16878
Drugi podaci
EC broj	1.13.11.20
Lokus	Hrom. 5 q23.2

Cistein dioksigenaza
	Cistein dioksigenaza 1, monomer, Human
Identifikatori
EC broj	1.13.11.20
CAS broj	37256-59-0
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Cistein dioksigenaza (CDO, CAS broj: 37256-59-0) je enzim sisara bez hem gvožđa koji katalizuje konverziju L-cisteina u cistein sulfinsku kiselinu (cistein sulfinat) putem inkorporacije di-kiseonika.^[1]

Cistein sulfinska kiselina se nalazi u tački grananja cisteinskog katabolizma, gde su moguća dva puta koja rezultiraju u formiranju taurina ili sulfata. Od cistein sulfinske kiseline-zavisni put metabolizma taurina sledi sintezu hipotaurina (2-aminoetan sulfinata), koji se naknadno oksiduje do taurina. Isto tako, cistein sulfinat može da podlegne transaminaciji i formira β-sulfinilpiruvat, koji se razlaže do piruvata i sulfita.* ^[2]

Reference

↑ Schousboe, Arne; Lajtha, Abel; Saransaari, Pirjo (2007). Amino acids and peptides in the nervous system. Berlin: Springer. ISBN 0-387-30342-1.
↑ McCoy JG, Bailey LJ, Bitto E, et al (February 2006). „Structure and mechanism of mouse cysteine dioxygenase”. Proc. Natl. Acad. Sci. U.S.A. 103 (9): 3084–9. DOI:10.1073/pnas.0509262103. PMC 1413891. PMID 16492780.

Literatura

Dodatna literatura

Sakakibara S, Yamaguchi K, Hosokawa Y, Kohashi N, Ueda I (February 1976). „Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase)”. Biochim. Biophys. Acta 422 (2): 273–9. PMID 2307.
Chai SC, Jerkins AA, Banik JJ, et al (March 2005). „Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase”. J. Biol. Chem. 280 (11): 9865–9. DOI:10.1074/jbc.M413733200. PMID 15623508. ^{[mrtav link]}
Schousboe, Arne; Lajtha, Abel; Saransaari, Pirjo (2007). Amino acids and peptides in the nervous system. Berlin: Springer. ISBN 0-387-30342-1.

[isbn0-387-30342-1-1] Schousboe, Arne; Lajtha, Abel; Saransaari, Pirjo (2007). Amino acids and peptides in the nervous system. Berlin: Springer. ISBN 0-387-30342-1.

[2] McCoy JG, Bailey LJ, Bitto E, et al (February 2006). „Structure and mechanism of mouse cysteine dioxygenase”. Proc. Natl. Acad. Sci. U.S.A. 103 (9): 3084–9. DOI:10.1073/pnas.0509262103. PMC 1413891. PMID 16492780.

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