Cistationinska g-lijaza

Cistationinska g-lijaza
Cistationinska g-lijaza tetramer, Human
Identifikatori
EC broj 4.4.1.1
CAS broj 9012-96-8
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Cistationinska g-lijaza (EC 4.4.1.1, homoserinska deaminaza, homoserinska dehidrataza, cistinska desulfhidraza, cisteinska desulfhidraza, gama-cistationaza, cistationaza, homoserinska deaminaza-cistationaza, gama-CTL, cistalisin, L-cistationinska cistein-lijaza (deaminacija)) je enzim sa sistematskim imenom L-cistationin cistein-lijaza (deaminacija, formira 2-oksobutanoat).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-cistationin + H2O L-cistein + NH3 + 2-oksobutanoat (sveukupna reakcija);;
(1a) L-cistationin L-cistein + 2-amoniobut-2-enoat
(1b) 2-amoniobut-2-enoat + H2O 2-oksobutanoat + NH3 (sponta reakcija)

Ovaj enzim je multifunkcionalni piridoksal-fosfatni protein.

Reference

  1. ↑ Braunstein, A.E. and Azarkh, R.M. (1950). „[Participation of vitamin B6 in enzymic formation of hydrogen sulfide from L-cysteine.]”. Dokl. Akad. Nauk. S.S.S.R. 71: 93-96. 
  2. ↑ Braunstein, A.E. and Azarkh, R.M. (1952). „[Phosphopyridoxal in aerobic deamination of homoserine and serine.]”. Dokl. Akad. Nauk. S.S.S.R. 85: 385-388. 
  3. ↑ Flavin, M. and Segal, A. (1964). „Purification and properties of the cystathionine γ-cleavage enzyme of Neurospora”. J. Biol. Chem. 239: 2220-2227. PMID 14209951. 
  4. ↑ Matsuo, Y. and Greenberg, D.M. (1959). „A crystalline enzyme that cleaves homoserine and cystathionine. III. Coenzyme resolution, activation, and inhibitors”. J. Biol. Chem. 234: 507-515. PMID 13641250. 
  5. ↑ Matsuo, Y. and Greenberg, D.M. (1959). „A crystalline enzyme that cleaves homoserine and cystathionine. IV. Mechanism of action, reversibility, and substrate specificity”. J. Biol. Chem. 234: 516-519. PMID 13641251. 

Literatura

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