Cijanatna hidrataza

Cijanatna hidrataza
Identifikatori
EC broj 4.2.1.104
CAS broj 37289-24-0
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Cijanatna hidrataza (EC 4.2.1.104, cijanatna lijaza, cijanatna hidrolaza, cijanatna aminohidrolaza, cijanatna C-N-lijaza) je enzim sa sistematskim imenom karbamat hidrolijaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju

cijanat + HCO3- + 2 H+ NH3 + 2 CO2 (sveukupna reakcija)
(1a) cijanat + HCO3- + H+ karbamat + CO2
(1b) karbamat + H+ NH3 + CO2 (spontana reakcija)

Ovaj enzim, koji je pristuan u bakterijama i biljkama, posreduje razlaganje cijanata.

Reference

  1. ↑ Anderson, P.M. (1980). „Purification and properties of the inducible enzyme cyanase”. Biochemistry 19: 2882-2888. PMID 6994799. 
  2. ↑ Johnson, W.V. and Anderson, P.M. (1987). „Bicarbonate is a recycling substrate for cyanase”. J. Biol. Chem. 262: 9021-9025. PMID 3110153. 
  3. ↑ Taussig, A. (1960). „T'he synthesis of the induced enzyme, "cyanase", in E. coli”. Biochim. Biophys. Acta 44: 510-519. PMID 13775509. 
  4. ↑ Taussig, A. (1965). „Some properties of the induced enzyme cyanase”. Can. J. Biochem. 43: 1063-1069. PMID 5322950. 
  5. ↑ Anderson, P.M., Korte, J.J. and Holcomb, T.A. (1994). „Reaction of the N-terminal methionine residues in cyanase with diethylpyrocarbonate”. Biochemistry 33: 14121-14125. PMID 7947823. 
  6. ↑ Kozliak, E.I., Fuchs, J.A., Guilloton, M.B. and Anderson, P.M. (1995). „Role of bicarbonate/CO2 in the inhibition of Escherichia coli growth by cyanate”. J. Bacteriol. 177: 3213-3219. PMID 7768821. 
  7. ↑ Walsh, M.A., Otwinowski, Z., Perrakis, A., Anderson, P.M. and Joachimiak, A. (2000). „Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site”. Structure 8: 505-514. PMID 10801492. 

Literatura

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