C5a peptidaza

C5a peptidaza
Identifikatori
EC broj 3.4.21.110
CAS broj 100179-39-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

C5a peptidaza (EC 3.4.21.110, streptokokalna C5a peptidaza, ScpA, ScpB, SCPA) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

Primarno dolazi do razlaganja u pozciji His67-Lys68 u ljudskom C5a, i u manjoj meri u poziciji Ala58-Ser59

Ovaj enzim za površinu vezana subtilisinu slična serinska peptidaza sa veoma uskom supstratnom specifičnošću.

Reference

  1. ↑ Wexler, D.E., Chenoweth, D.E. and Cleary, P.P. (1985). „Mechanism of action of the group A streptococcal C5a inactivator”. Proc. Natl. Acad. Sci. USA 82: 8144-8148. PMID 3906656. 
  2. ↑ Bohnsack, J.F., Mollison, K.W., Buko, A.M., Ashworth, J.C. and Hill, H.R. (1991). „Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus”. Biochem. J. 273: 635-640. PMID 1996961. 
  3. ↑ Cleary, P.P., Prahbu, U., Dale, J.B., Wexler, D.E. and Handley, J. (1992). „Streptococcal C5a peptidase is a highly specific endopeptidase”. Infect. Immun. 60: 5219-5223. PMID 1452354. 
  4. ↑ Anderson, E.T., Wetherell, M.G., Winter, L.A., Olmsted, S.B., Cleary, P.P. and Matsuka, Y.V. (2002). „Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes”. Eur. J. Biochem. 269: 4839-4851. PMID 12354115. 
  5. ↑ Stafslien, D.K. and Cleary, P.P. (2000). „Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate”. J. Bacteriol. 182: 3254-3258. PMID 10809707. 
  6. ↑ Terao, Y., Yamaguchi, M., Hamada, S. and Kawabata, S. (2006). „Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils”. J. Biol. Chem. 281: 14215-14223. PMID 16565520. 

Literatura

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