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C3/C5 konvertaza alternativno komplementnog puta
Identifikatori
EC broj	3.4.21.47
CAS broj	80295-67-6
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

C3/C5 konvertaza alternativno komplementnog puta (EC 3.4.21.47, komplementna komponenta C3/C5 konvertaza (alternativna), proenzimski faktor B, properdinski faktor B, C3 proaktivator, glicinom bogati beta-glikoprotein, toplotno-labilni faktor, C3 konvertaza, C3b,Bb,CVF,Bb,C5 konvertaza, (C3b)n,Bb, komplement C 3(C 5) konvertaza (amplifikacija), konvertaza alternativnog komplementnog puta C3(C5), C5 konvertaza, CVF,Bb, (CVF)-zavisni glicinom-bogati-beta-glukoprotein, C3 konvertaza zavisna od faktora kobrinog venuma) je enzim.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje Arg-Ser veze u alfa-lancu komplementne komponente C3 čime se formira C3a i C3b, i Arg- veze u alfa-lancu komplementne komponente C5 čime se formira C5a i C5b

Ovaj enzim je bimolekulski kompleks komplementnog fragmenta Bb sa bilo C3b ili faktorom kobrinog venuma.

Reference

↑ Kerr, M.A. (1981). „Human factor B”. Methods Enzymol. 80: 102-112. PMID 7043188.
↑ Morley, B.J. and Campbell, R.D. (1984). „Internal homologies of the Ba fragment from human complement component Factor B, as a class III MHC antigen”. EMBO J. 3: 153-157. PMID 6323161.
↑ Müller-Eberhard, H.J. (1988). „Molecular organization and function of the complement system”. Annu. Rev. Biochem. 57: 321-347. PMID 3052276.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Alternative-complement-pathway+C3/C5+convertase

[1] Kerr, M.A. (1981). „Human factor B”. Methods Enzymol. 80: 102-112. PMID 7043188.

[2] Morley, B.J. and Campbell, R.D. (1984). „Internal homologies of the Ba fragment from human complement component Factor B, as a class III MHC antigen”. EMBO J. 3: 153-157. PMID 6323161.

[3] Müller-Eberhard, H.J. (1988). „Molecular organization and function of the complement system”. Annu. Rev. Biochem. 57: 321-347. PMID 3052276.

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