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Bromid peroksidaza
Identifikatori
EC broj	1.11.1.18
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Bromid peroksidaza (EC 1.11.1.18, bromoperoksidaza, haloperoksidaza (nespecifična), eozinofilna peroksidaza) je enzim sa sistematskim imenom bromid:vodonik-peroksid oksidoreduktaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju:

RH + HBr + H₂O₂

\rightleftharpoons

RBr + 2H₂O

Ove bromoperoksidaze crvenih i smeđih morskih algi (Rhodophyta i Phaeophyta) sadrže vanadat. One katalizuju brominaciju niza organskih molekula kao što su seskviterpeni, formirajući stabilne C-Br veze. Bromoperoksidaze takođe oksiduju jodide.

Reference

↑ De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R (1986). „Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina”. Biochim. Biophys. Acta 872: 104-115.
↑ Tromp, M.G., Olafsson, G., Krenn, B.E. and Wever, R. (1990). „Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum”. Biochim. Biophys. Acta 1040: 192-198. PMID 2400770.
↑ Isupov, M.N., Dalby, A.R., Brindley, A.A., Izumi, Y., Tanabe, T., Murshudov, G.N. and Littlechild, J.A. (2000). „Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis”. J. Mol. Biol. 299: 1035-1049. PMID 10843856.
↑ Carter-Franklin, J.N. and Butler, A. (2004). „Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products”. J. Am. Chem. Soc. 126: 15060-15066. PMID 15548002.
↑ Ohshiro, T., Littlechild, J., Garcia-Rodriguez, E., Isupov, M.N., Iida, Y., Kobayashi, T. and Izumi, Y. (2004). „Modification of halogen specificity of a vanadium-dependent bromoperoxidase”. Protein Sci. 13: 1566-1571. PMID 15133166.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Bromide+peroxidase

[1] De Boer, E., Tromp, M.G.M., Plat, H., Krenn, G.E. and Wever, R (1986). „Vanadium(v) as an essential element for haloperoxidase activity in marine brown-algae - purification and characterization of a vanadium(V)-containing bromoperoxidase from Laminaria saccharina”. Biochim. Biophys. Acta 872: 104-115.

[2] Tromp, M.G., Olafsson, G., Krenn, B.E. and Wever, R. (1990). „Some structural aspects of vanadium bromoperoxidase from Ascophyllum nodosum”. Biochim. Biophys. Acta 1040: 192-198. PMID 2400770.

[3] Isupov, M.N., Dalby, A.R., Brindley, A.A., Izumi, Y., Tanabe, T., Murshudov, G.N. and Littlechild, J.A. (2000). „Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis”. J. Mol. Biol. 299: 1035-1049. PMID 10843856.

[4] Carter-Franklin, J.N. and Butler, A. (2004). „Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products”. J. Am. Chem. Soc. 126: 15060-15066. PMID 15548002.

[5] Ohshiro, T., Littlechild, J., Garcia-Rodriguez, E., Isupov, M.N., Iida, Y., Kobayashi, T. and Izumi, Y. (2004). „Modification of halogen specificity of a vanadium-dependent bromoperoxidase”. Protein Sci. 13: 1566-1571. PMID 15133166.

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