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B-adrenergički-receptor kinaza
Identifikatori
EC broj	2.7.11.15
CAS broj	102925-39-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

B-adrenergički-receptor kinaza (EC 2.7.11.15, ATP:beta-adrenergički-receptor fosfotransferaza, beta-adrenergički receptor-specifična kinaza, beta-AR kinaza, beta-ARK, beta-ARK 1, beta-ARK 2, beta-receptor kinaza, GRK2, GRK3, beta-adrenergički-receptor kinaza (fosforilacija), beta2ARK, betaARK1, beta-adrenoceptor kinaza, beta-adrenoceptor kinaza 1, beta-adrenoceptor kinaza 2, ADRBK1, BARK1, adrenergički receptor kinaza, STK15) je enzim sa sistematskim imenom ATP:(beta-adrenergic receptor) fosfotransferaza.^[1]^[2]^[3]^[4]^[5] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [beta-adrenergički receptor]

\rightleftharpoons

ADP + fosfo-[beta-adrenergički receptor]

G-protein je neophodan za aktivaciju i stoga ovaj enzim pripada familiji G-protein-zavisnih receptorskih kinaza (GRKs).

Reference

↑ Benovic, J.L., Mayor, F., Jr., Staniszewski, C., Lefkowitz, R.J. and Caron, M.G. (1987). „Purification and characterization of the β-adrenergic receptor kinase”. J. Biol. Chem. 262: 9026-9032. PMID 3036840.
↑ Kim, C.M., Dion, S.B., Onorato, J.J. and Benovic, J.L. (1993). „Expression and characterization of two β-adrenergic receptor kinase isoforms using the baculovirus expression system”. Receptor 3: 39-55. PMID 8394172.
↑ Laugwitz, K.L., Kronsbein, K., Schmitt, M., Hoffmann, K., Seyfarth, M., Schomig, A. and Ungerer, M. (1997). „Characterization and inhibition of β-adrenergic receptor kinase in intact myocytes”. Cardiovasc Res 35: 324-333. PMID 9349395.
↑ Ferguson, S.S., Menard, L., Barak, L.S., Koch, W.J., Colapietro, A.M. and Caron, M.G. (1995). „Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by betaARK1”. J. Biol. Chem. 270: 24782-24789. PMID 7559596.
↑ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). „Non-visual GRKs: are we seeing the whole picture?”. Trends Pharmacol. Sci. 24: 626-633. PMID 14654303.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Beta-adrenergic-receptor+kinase

[1] Benovic, J.L., Mayor, F., Jr., Staniszewski, C., Lefkowitz, R.J. and Caron, M.G. (1987). „Purification and characterization of the β-adrenergic receptor kinase”. J. Biol. Chem. 262: 9026-9032. PMID 3036840.

[2] Kim, C.M., Dion, S.B., Onorato, J.J. and Benovic, J.L. (1993). „Expression and characterization of two β-adrenergic receptor kinase isoforms using the baculovirus expression system”. Receptor 3: 39-55. PMID 8394172.

[3] Laugwitz, K.L., Kronsbein, K., Schmitt, M., Hoffmann, K., Seyfarth, M., Schomig, A. and Ungerer, M. (1997). „Characterization and inhibition of β-adrenergic receptor kinase in intact myocytes”. Cardiovasc Res 35: 324-333. PMID 9349395.

[4] Ferguson, S.S., Menard, L., Barak, L.S., Koch, W.J., Colapietro, A.M. and Caron, M.G. (1995). „Role of phosphorylation in agonist-promoted β2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by betaARK1”. J. Biol. Chem. 270: 24782-24789. PMID 7559596.

[5] Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). „Non-visual GRKs: are we seeing the whole picture?”. Trends Pharmacol. Sci. 24: 626-633. PMID 14654303.

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