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Aralkilamin dehidrogenaza
Identifikatori
EC broj	1.4.99.4
CAS broj	85030-73-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Aralkilamin dehidrogenaza (EC 1.4.99.4, aromatična amin dehidrogenaza, dehidrogenaza, arilamin, tiramin dehidrogenaza, aralkilamin:(akceptor) oksidoreduktaza (deaminacija)) je enzim sa sistematskim imenom aralkilamin:akceptor oksidoreduktaza (deaminacija).^[1] Ovaj enzim katalizuje sledeću hemijsku reakciju:

RCH₂NH₂ + H₂O + akceptor

\rightleftharpoons

RCHO + NH₃ + redukovani akceptor

Fenazin metosulfat može da deluje kao akceptor. Ovaj enzim deluje na aromatične amine i u manjoj meri na neke dugolančane alifatične amine. On nije aktivan na metilaminu ili etilaminu (cf. EC 1.4.99.3 amin dehidrogenaza).

Reference

↑ Iwaki, M., Yagi, T., Horiike, K., Saeki, Y., Ushijima, T. and Nozaki, M. (1983). „Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp”. Arch. Biochem. Biophys. 220: 253-262. PMID 6830237.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Aralkylamine+dehydrogenase

[1] Iwaki, M., Yagi, T., Horiike, K., Saeki, Y., Ushijima, T. and Nozaki, M. (1983). „Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp”. Arch. Biochem. Biophys. 220: 253-262. PMID 6830237.

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