PROFILPELAJAR.COM

Aminodezoksihorizmat sintaza
Identifikatori
EC broj	2.6.1.85
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Aminodezoksihorizmat sintaza (EC 2.6.1.85, ADC sintaza, 4-amino-4-dezoksihorizmatna sintaza, PabB, horizmat:L-glutamin amido-ligaza) je enzim sa sistematskim imenom horizmat:L-glutamin aminotransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

horizmat + L-glutamin

\rightleftharpoons

4-amino-4-dezoksihorizmat + L-glutamat

Ovaj enzim se sastoji od dva dela, PabA i PabB. U odsustvu PabA i glutamina, PabB konvertuje amonijak i horizmat u 4-amino-4-dezoksihorizmat (u prisustvu Mg²⁺). PabA konvertuje glutamin u glutamat samo kad je prisutna stohiometrijka količina PabB. Ovaj enzim se spreže sa EC 4.1.3.38, aminodezoksihorizmatnom lijazom, da formira 4-aminobenzoat.

Reference

↑ Ye, Q.Z., Liu, J. and Walsh, C.T. (1990). „p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase”. Proc. Natl. Acad. Sci. USA 87: 9391-9395. PMID 2251281.
↑ Viswanathan, V.K., Green, J.M. and Nichols, B.P. (1995). „Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli”. J. Bacteriol. 177: 5918-5923. PMID 7592344.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Aminodeoxychorismate+synthase

[1] Ye, Q.Z., Liu, J. and Walsh, C.T. (1990). „p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase”. Proc. Natl. Acad. Sci. USA 87: 9391-9395. PMID 2251281.

[2] Viswanathan, V.K., Green, J.M. and Nichols, B.P. (1995). „Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli”. J. Bacteriol. 177: 5918-5923. PMID 7592344.

[1]

[2]