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Aminoacilaza
Identifikatori
EC broj	3.5.1.14
CAS broj	9012-37-7
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Aminoacilaza (EC 3.5.1.14, dehidropeptidaza II, histozim, hipurikaza, benzamidaza, acilaza I, hipuraza, amidokiselinska deacilaza, L-aminoacilaza, acilaza, aminoacilaza I, L-aminokiselinska acilaza, alfa-N-acilaminokiselinska hidrolaza, dugoacilna amidoacilaza, kratkoacilna amidoacilaza) je enzim sa sistematskim imenom N-acil-L-amino-kiselina amidohidrolaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

N-acil-L-aminokiselina + H₂O

\rightleftharpoons

karboksilat + L-aminokiselina

Ovaj enzim ima široku specifičnost. On takođe hidrolizuje dehidropeptide.

Reference

↑ Birnbaum, S.M., Levintow, L., Kingsley, R.B. and Greenstein, J.P. (1952). „Specificity of amino acid acylases”. J. Biol. Chem. 194: 455-470. PMID 14927637.
↑ Fones, W.S. and Lee, M. (1953). „Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase”. J. Biol. Chem. 201: 847-856. PMID 13061423.
↑ Park, R.W. and Fox, S.W. (1960). „An acylase system related to the utilization of benzoylamino acids by Lactobacillus arabinosus”. J. Biol. Chem. 235: 3193-3197. PMID 13732833.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Aminoacylase

[1] Birnbaum, S.M., Levintow, L., Kingsley, R.B. and Greenstein, J.P. (1952). „Specificity of amino acid acylases”. J. Biol. Chem. 194: 455-470. PMID 14927637.

[2] Fones, W.S. and Lee, M. (1953). „Hydrolysis of N-acyl derivatives of alanine and phenylalanine by acylase I and carboxypeptidase”. J. Biol. Chem. 201: 847-856. PMID 13061423.

[3] Park, R.W. and Fox, S.W. (1960). „An acylase system related to the utilization of benzoylamino acids by Lactobacillus arabinosus”. J. Biol. Chem. 235: 3193-3197. PMID 13732833.

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