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Alifatična aldoksimna dehidrataza
Identifikatori
EC broj	4.99.1.5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

Alifatična aldoksimna dehidrataza (EC 4.99.1.5, OxdA, alifatična aldoksimska hidrolijaza) je enzim sa sistematskim imenom alifatični aldoksim hidrolijaza (formira alifatični-nitril).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

alifatični aldoksim

\rightleftharpoons

alifatični nitril + H₂O

Enzim iz Pseudomonas hlororaphis sadrži Ca²⁺ i protohem IX.

Reference

↑ Oinuma, K.-I., Hashimoto, Y., Konishi, K., Goda, M., Noguchi, T., Higashibata, H. and Kobayashi, M. (2003). „Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23: Sequencing, gene expression, purification and characterization”. J. Biol. Chem. 278: 29600-29608. PMID 12773527.
↑ Xie, S.X., Kato, Y., Komeda, H., Yoshida, S. and Asano, Y. (2003). „A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4”. Biochemistry 42: 12056-12066. PMID 14556637.
↑ Kato, Y., Yoshida, S., Xie, S.-X. and Asano, Y. (2004). „Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771”. J. Biosci. Bioeng. 97: 250-259. PMID 16233624.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Aliphatic+aldoxime+dehydratase

[1] Oinuma, K.-I., Hashimoto, Y., Konishi, K., Goda, M., Noguchi, T., Higashibata, H. and Kobayashi, M. (2003). „Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23: Sequencing, gene expression, purification and characterization”. J. Biol. Chem. 278: 29600-29608. PMID 12773527.

[2] Xie, S.X., Kato, Y., Komeda, H., Yoshida, S. and Asano, Y. (2003). „A gene cluster responsible for alkylaldoxime metabolism coexisting with nitrile hydratase and amidase in Rhodococcus globerulus A-4”. Biochemistry 42: 12056-12066. PMID 14556637.

[3] Kato, Y., Yoshida, S., Xie, S.-X. and Asano, Y. (2004). „Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771”. J. Biosci. Bioeng. 97: 250-259. PMID 16233624.

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