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A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza
Identifikatori
EC broj	2.4.1.201
CAS broj	119699-68-2
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza (EC 2.4.1.201, N-acetilglukozaminiltransferaza VI, N-glikozil-oligosaharid-glikoprotein N-acetilglukozaminiltransferaza VI, uridin difosfoacetilglukozamin-glikopeptid beta-1->4-acetilglukozaminiltransferaza VI, manozil-glikoprotein beta-1,4-N-acetilglukozaminiltransferaza, GnTVI) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:2,6-bis(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-glikoprotein 4-beta-N-acetil-D-glukozaminiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + 2,6-bis(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-R

\rightleftharpoons

UDP + 2,4,6-tris(N-acetil-beta-D-glukozaminil)-alfa-D-manozil-R

R označava ostatak N-vezanog oligosaharida u glikoproteinskom akceptoru.

Reference

↑ Brockhausen, I., Hull, E., Hindsgaul, O., Schachter, H., Shah, R.N., Michnick, S.W. and Carver, J.P. (1989). „Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc β1-6 (GlcNAc β1-2)Man α-R (GlcNAc to Man) β-4-N-acetylglucosaminyltransferase VI”. J. Biol. Chem. 264: 11211-11221. PMID 2525556.
↑ Taguchi, T., Ogawa, T., Inoue, S., Inoue, Y., Sakamoto, Y., Korekane, H. and Taniguchi, N. (2000). „Purification and characterization of UDP-GlcNAc:GlcNAcβ1-6(GlcNAcβ1-2)Manα1-R [GlcNAc to Man]-β1,4-N-acetylglucosaminyltransferase VI from hen oviduct”. J. Biol. Chem. 275: 32598-32602. PMID 10903319.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH Alpha-1,6-mannosyl-glycoprotein+4-beta-N-acetylglucosaminyltransferase

[1] Brockhausen, I., Hull, E., Hindsgaul, O., Schachter, H., Shah, R.N., Michnick, S.W. and Carver, J.P. (1989). „Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc β1-6 (GlcNAc β1-2)Man α-R (GlcNAc to Man) β-4-N-acetylglucosaminyltransferase VI”. J. Biol. Chem. 264: 11211-11221. PMID 2525556.

[2] Taguchi, T., Ogawa, T., Inoue, S., Inoue, Y., Sakamoto, Y., Korekane, H. and Taniguchi, N. (2000). „Purification and characterization of UDP-GlcNAc:GlcNAcβ1-6(GlcNAcβ1-2)Manα1-R [GlcNAc to Man]-β1,4-N-acetylglucosaminyltransferase VI from hen oviduct”. J. Biol. Chem. 275: 32598-32602. PMID 10903319.

[1]

[2]

A-1,6-manozil-glikoprotein 4-b-N-acetilglukozaminiltransferaza

Reference

Literatura

Vanjske veze

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